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Chemical-Induced Skin Carcinogenesis Model Using Dimethylbenz[a]Anthracene and 12-O-Tetradecanoyl Phorbol-13-Acetate DMBA-TPA
Published on: December 19, 2019
Xeroderma Pigmentosum Associated with Squamous and Basal Cell Carcinoma in Pakistan: A Case Series
Mumtaz Ali Khan1, Nighat Akbar, Asim Saeed
1At the National Institute of Health, Islamabad, Pakistan, Mumtaz Ali Khan, MD, MsPH, MS, MSc, MPH, is Senior Scientific Officer (Epidemiology), Nighat Akbar, MBBS, MRCP, is Senior Scientific Officer, Asim Saeed, MBBS, MPhil, is Microbiologist, Afreenish Amir, MBBS, MPhil, PhD, is Technical Officer AMR, and Aamer Ikram, MBBS, DCP, MCPS, FCPS, PhD, is Executive Director. Zikria Saleem, PharmD, MPhil, PhD, is Assistant Professor, Department of Pharmacy Practice, Faculty of Pharmacy, University of Lahore, Pakistan. The authors have disclosed no financial relationships related to this article. Submitted November 4, 2020; accepted in revised form January 7, 2021.
Abstract:
Xeroderma pigmentosum (XP) is an autosomal recessive condition characterized by an extreme sensitivity to UV rays from sunlight. It presents clinically with progressive pigmentary abnormalities and an increased incidence of skin and mucous membrane cancers at sun-exposed sites. Parental consanguinity is a significant risk factor. Previously, cases of XP have been reported from various regions of Pakistan including Larkana, Sibbi, Karachi, Lahore, and District Dir in 1993, 2009, and 2010. Genetic studies have been conducted on seven consanguineous families with XP belonging to the Khosa tribe of Baloch ethnicity. In May 2018, XP was reported in four siblings in a family from a small village in Sindh Province, Pakistan. Current surveillance has been carried out in the tribal village of Lundi Khosa, District Kachhi at Baluchistan, Pakistan. The disease has been endemic in the tribe since 1986, although it was brought under control in the last few years. This case report describes five patients (aged 3-12 years) with XP who have developed nonmelanoma skin malignancies.
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