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Related Concept Videos

Blood Transfusion01:15

Blood Transfusion

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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
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Comparative metavirome analysis in polytransfused patients.

I N Valença1,2, F A Rós1,2, V S Zucherato2

  • 1Programa de Pós-Graduação em Oncologia Clínica, Células Tronco e Terapia Celular, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|October 20, 2021
PubMed
Summary
This summary is machine-generated.

Polytransfused patients with sickle cell disease (SCD) and beta-thalassemia exhibit distinct viral profiles. Human pegivirus-1 (HPgV-1) dominated in SCD patients, while Torque teno virus (TTV) was abundant in beta-thalassemia patients, suggesting potential biomarker roles.

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Area of Science:

  • Virology
  • Hematology
  • Genetics

Background:

  • Polytransfused patients with sickle cell disease (SCD) and beta-thalassemia face high risks of parenterally transmitted infections.
  • Limited data exists on the virome composition in these patient groups and the impact of hemotherapy.

Purpose of the Study:

  • To compare viral diversity, abundance, and specific viral profiles between SCD and beta-thalassemia patients.
  • To investigate the influence of transfusion frequency and disease characteristics on the blood virome.

Main Methods:

  • Next-generation sequencing (NGS) was employed to analyze the virome.
  • The study included 30 beta-thalassemia major patients, 45 SCD patients, and 16 healthy blood donors.
  • Viral abundance and genotypes were compared across groups.

Main Results:

  • Commensal viruses, primarily Torque teno virus (TTV) and human pegivirus-1 (HPgV-1), were identified in all groups.
  • HPgV-1 reads were dominant in the SCD cohort.
  • Thalassemic patients exhibited significantly higher TTV abundance, including diverse genotypes.

Conclusions:

  • The commensal virome in polytransfused patients may be influenced by transfusion frequency and underlying hematological conditions.
  • TTV and HPgV-1 could serve as potential genetic biomarkers for SCD and beta-thalassemia.
  • Further research is needed to confirm the relationship between blood virome and transfusion treatments.