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Updated: Oct 16, 2025
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Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
Published on: November 6, 2018
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VEGETABLE CELLULOSE NANOFIBER DRESSING AIDS IN THE HEALING PROCESS OF THIRD-DEGREE BURNS? STUDY ON RATS.
Milka Lie Takejima1,2, Maria Angelica Baron Magalhães1, Jurandir Marcondes Ribas Filho1
1Mackenzie Evangelical Faculty of Paraná, Curitiba, PR, Brazil.
Summary
Pinus sp cellulose membrane effectively treats third-degree burns, showing wound contraction and healing comparable to bacterial cellulose. This biomaterial offers a promising alternative for burn wound management.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Wound Healing Research
Background:
- Third-degree burns present significant therapeutic challenges.
- Pinus sp cellulose, a plant-derived biomaterial, shares properties with bacterial cellulose, suggesting potential in wound care.
Purpose of the Study:
- To assess the safety and efficacy of a Pinus sp cellulose membrane for treating third-degree burns.
- To compare its performance against commercially available bacterial cellulose membranes.
Main Methods:
- A third-degree burn model was established in 33 Wistar rats.
- Animals were divided into three groups: gauze dressing, bacterial cellulose membrane, and Pinus sp cellulose membrane.
- Wound healing was evaluated over 15 days via clinical, macroscopic, and microscopic analyses.
Main Results:
- Cellulose membranes protected wounds from injury during dressing changes, unlike gauze.
- Pinus sp cellulose and bacterial cellulose groups exhibited greater wound contraction than the control group.
- Microscopic examination indicated advanced healing with mature collagen in all groups.
Conclusions:
- The Pinus sp cellulose membrane demonstrated comparable efficacy to bacterial cellulose in treating third-degree burns.
- This plant-derived biomaterial is a viable option for burn wound treatment.
