The human microbiome in immunobullous disorders and lichen planus

Area of Science:

• Immunology
• Microbiology
• Dermatology

Background:

• Rising incidence of autoimmune diseases over decades.
• Genetic factors are insufficient to explain autoimmune disease development.
• Microbiome dysbiosis is an emerging mechanism in autoimmune pathogenesis.

Purpose of the Study:

• To review the role of the microbiome in autoimmune diseases.
• To examine microbiome contributions to acquired immunobullous and lichenoid diseases.
• To discuss potential therapeutic and preventive strategies targeting the microbiome.

Main Methods:

• Literature review of current research on microbiome and autoimmunity.
• Focus on mucocutaneous disorders including psoriasis, atopic dermatitis, acne, rosacea, lichen planus, and acquired immunobullous diseases.
• Analysis of mechanisms linking microbiome dysbiosis to disease pathogenesis.

Main Results:

• The microbiome's role in common skin disorders is well-established.
• Limited research exists on the microbiome's impact on lichen planus and acquired immunobullous diseases.
• Dysbiosis is implicated in the development and exacerbation of these mucocutaneous conditions.

Conclusions:

• The microbiome is a significant factor in autoimmune disease development.
• Understanding microbiome-disease links offers new avenues for prevention and treatment.
• Further research is needed for lichen planus and acquired immunobullous diseases.