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External quality assessment of serum indices: Spanish SEQC-ML program
Rubén Gómez Rioja1, Monserrat Ventura2, María Antonia Llopis3
1Laboratory Medicine, La Paz - Cantoblanco - Carlos III University Hospital, Madrid, Spain.
Clinical Chemistry and Laboratory Medicine
|October 20, 2021
Summary
External quality assessment programs for serum indices help laboratories improve sample quality. The Spanish Society of Laboratory Medicine
Area of Science:
- Clinical Chemistry
- Laboratory Medicine
- Quality Assessment
Background:
- Serum indices are crucial for assessing sample quality in clinical chemistry.
- Quantitative results from instruments enable performance evaluation similar to biochemical tests.
Purpose of the Study:
- To present the results of the first three years of an external quality program for serum indices.
- To evaluate the diagnostic performance and identify inter-instrument bias.
Main Methods:
- Utilized three lyophilized materials for monthly external quality assessment.
- Employed four different quality control materials quarterly for accuracy evaluation.
- Established consensus values among homogeneous groups for assigned values.
Main Results:
- Imprecision for the three indices ranged from 3% to 9% across instruments.
- Significant inter-instrument differences were noted for major platforms.
- Analytical Performance Specifications (APS) were proposed in 2020 for hemolytic, icteric, and lipemic indices.
Conclusions:
- Serum indices significantly impact laboratory test result quality and reliability.
- Proficiency testing programs promote harmonization between providers and laboratories.
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