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Updated: Oct 16, 2025
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Author Spotlight: Characterizing DNA Replication of Pathogenic Repeats to Uncover Mechanisms of Replication Fork Stalling and Expansion
Published on: September 13, 2024
934
[Structural, Functional, and Evolutionary Characteristics of Proteins with Repeats]
E I Deryusheva1,2, A V Machulin3, O V Galzitskaya4,5,6
1Institute of Biological Instrumentation, Pushchino Biological Research Center, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290 Russia.
Molekuliarnaia Biologiia
|October 21, 2021
Summary
This review explores proteins with structural repeats, covering their classification, function, and evolutionary development. It highlights their potential as drug design scaffolds and role in disease pathogenesis.
Area of Science:
- * Structural biology and bioinformatics.
- * Molecular evolution and drug discovery.
Background:
- * Proteins with structural repeats are fundamental biological building blocks.
- * Understanding their diversity and function is crucial for biological and medical research.
Purpose of the Study:
- * To systematically review the classification, distribution, structure, and function of repeat-containing proteins.
- * To explore modern methods for identifying structural repeats and utilizing protein domain databases.
- * To analyze the role of these proteins in disease and their potential in drug design.
Main Methods:
- * Comprehensive literature review and data systematization.
- * Analysis of modern computational approaches for repeat identification.
- * Examination of specialized protein domain databases.
Main Results:
- * A structured overview of repeat-containing protein classification and distribution.
- * Insights into the structural features and functional roles of these proteins.
- * Discussion on the application of repeat proteins in drug design and their involvement in diseases.
Conclusions:
- * Repeat-containing proteins are versatile and significant in biological systems.
- * Advanced computational tools and databases enhance the study of protein repeats.
- * These proteins offer promising avenues for therapeutic development and understanding disease mechanisms.
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