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Determining Ciliary Function and Membrane Impermeability of the Pseudostratified Lung Airway Epithelium

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E-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction.

Hasan Yuksel¹, Merve Ocalan², Ozge Yilmaz¹

¹Department of Pediatric Allergy and Pulmonology, Faculty of Medicine, Celal Bayar University, Manisa, Turkey.

Frontiers in Physiology

|October 21, 2021

Summary

E-cadherin, crucial for airway epithelial barriers, protects against environmental pollutants. Its dysfunction is linked to respiratory diseases, and its abnormal activation can be harmful.

Keywords:

E-cadherin adherens junction epithelial cells epithelial mesenchymal transition respiratory epithelial barrier

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Area of Science:

Respiratory biology
Cellular adhesion
Immunology

Background:

The airway epithelium forms a critical barrier against inhaled environmental factors like pollutants and allergens.
Intercellular junctional proteins are key to maintaining this epithelial barrier's integrity and homeostasis.
E-cadherin, a calcium-dependent adhesion molecule, is vital for forming and maintaining the epithelial barrier.

Purpose of the Study:

To review the role of E-cadherin in airway epithelial barrier formation.
To examine E-cadherin's status following exposure to environmental triggers.
To discuss respiratory diseases linked to E-cadherin dysfunction and its potentially noxious abnormal activation.

Main Methods:

Literature review of studies on E-cadherin in airway epithelium.
Analysis of E-cadherin's role in barrier function.
Examination of E-cadherin's involvement in respiratory disease pathogenesis.

Main Results:

E-cadherin is essential for the physical integrity of the airway epithelial barrier.
Environmental exposures can alter E-cadherin expression and function.
Dysfunctional E-cadherin is associated with various respiratory conditions.

Conclusions:

E-cadherin plays a multifaceted role in airway epithelial barrier defense and homeostasis.
Environmental insults impact E-cadherin, contributing to respiratory disease development.
Understanding E-cadherin's dual role (protective and potentially harmful) is crucial for therapeutic strategies.