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Anticoagulant Drugs: Low-Molecular-Weight Heparins

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...

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Related Experiment Video

Updated: Oct 16, 2025

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

Published on: October 26, 2016

A heparin-functionalized covered stent prepared by plasma technology.

Qing Zhu¹, Ping Ye¹, Fang Guo¹

¹47863University of Shanghai for Science and Technology, Shanghai, China.

Journal of Biomaterials Applications

|October 21, 2021

Summary

This study developed a heparin-functionalized covered stent (HPLCS) using plasma technology. The novel stent demonstrates sustained heparinization, showing promise for improved medical device performance.

Keywords:

Heparin covered stent glutaraldehyde heparin-functionalized covered stent plasma technology

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Last Updated: Oct 16, 2025

Fabrication of Small Caliber Stent-grafts Using Electrospinning and Balloon Expandable Bare Metal Stents

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Published on: October 26, 2016

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

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Published on: June 23, 2018

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention

Published on: September 18, 2015

Area of Science:

Biomaterials Science
Medical Device Engineering
Surface Chemistry

Background:

Covered stents are crucial in preventing complications like thrombosis.
Improving the biocompatibility and antithrombotic properties of stent surfaces is an ongoing challenge.
Heparin coating is a common strategy to enhance the hemocompatibility of medical devices.

Purpose of the Study:

To develop a robust method for preparing heparin-functionalized covered stents (HPLCS).
To optimize the parameters for plasma treatment and heparin grafting.
To evaluate the in vivo stability and efficacy of the heparin coating.

Main Methods:

Surface modification of covered stents using plasma technology to introduce amino groups.
Grafting of glutaraldehyde and heparin onto the stent surface.
Optimization of plasma treatment power, time, and reagent concentrations.
In vitro and in vivo evaluation of heparin coating stability and titer.

Main Results:

Successful preparation of heparin-functionalized covered stents (HPLCS) with optimized parameters.
Achieved a high initial heparin titer of 1.23 ± 0.03 IU/cm².
Demonstrated excellent in vivo stability, retaining a heparin titer of 0.93 ± 0.05 IU/cm² after 6 months in pigs.

Conclusions:

Plasma-assisted surface functionalization is an effective method for preparing stable heparin-coated stents.
The developed HPLCS exhibits promising long-term heparinization for enhanced hemocompatibility.
This technique offers a valuable approach for creating advanced heparin-eluting medical devices.