Cerebellar liponeurocytoma in an elderly patient: DNA methylation profiling as a helpful diagnostic tool

Cerebellar liponeurocytoma is a rare primary cerebellar neoplasm that mostly occurs in adults, however, it is rare in the elderly.

We report, in a 79-year-old female, a recurrent vermian cerebellar mass that was previously diagnosed as primary cerebellar tumor with neuroendocrine differentiation. The recurrent lesion showed anaplastic features and lipidization.

DNA methylation profiling was performed for the recurrent tumor, which showed a high score match for cerebellar liponeurocytoma.

This report confirms the usefulness of DNA methylation profiling for the diagnosis of challenging CNS tumors.