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Following the Dynamics of Structural Variants in Experimentally Evolved Populations
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Nucleotide Substitutions during Speciation may Explain Substitution Rate Variation.

Thijs Janzen1, Folmer Bokma2, Rampal S Etienne1

  • 1Groningen Institute for Evolutionary Life Sciences, University of Groningen, Box 11103, 9700 CC Groningen, The Netherlands.

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|October 21, 2021
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Summary
This summary is machine-generated.

Elevated mutation rates during speciation events may explain variation in substitution rates across the tree of life. This finding impacts phylogenetic reconstruction by shifting mutations from branches to speciation events.

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Area of Science:

  • Evolutionary biology
  • Molecular evolution
  • Phylogenetics

Background:

  • Mutation rate variation is observed across evolutionary lineages, despite conserved mutation mechanisms.
  • Relaxed molecular clocks are commonly used in phylogenetic reconstruction to account for rate variation, but lack biological mechanism.
  • Existing models do not fully explain the observed substitution rate variation.

Purpose of the Study:

  • To propose and investigate the hypothesis that elevated mutation rates during speciation events contribute to observed substitution rate variation.
  • To assess the impact of this proposed mechanism on phylogenetic reconstruction and molecular clock models.

Main Methods:

  • Computer simulations were used to model phylogenetic scenarios.
  • Simulations incorporated a shift of mutations from evolutionary branches to speciation events.
  • The impact on phylogenetic branching time inference and the fit to molecular clock models were analyzed.

Main Results:

  • Shifting mutations to speciation events significantly impacts the inference of branching times in phylogenetic reconstruction.
  • Nucleotide alignments generated under this model are better described by a relaxed molecular clock than a strict one.
  • The proposed mechanism offers a potential biological explanation for substitution rate variation.

Conclusions:

  • Elevated mutation rates during speciation represent a plausible biological factor contributing to substitution rate variation across the tree of life.
  • This mechanism provides a more biologically grounded explanation for patterns typically modeled by relaxed molecular clocks.
  • Further research can explore empirical evidence for elevated mutation rates during speciation events.