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Related Experiment Video

Updated: Oct 16, 2025

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

Oral Iron Absorption Test: A Simple Test with Relevance in the Clinical Setting.

Joseph Gardyn¹, Noa Chapal², Sharon Floru³

¹Lev Hapark Clinic, Clalit Medical Services, Raanana, Israel.

The Israel Medical Association Journal : IMAJ

|October 21, 2021

Summary

The oral iron absorption test (OIAT) is a simple method to assess iron absorption in patients with iron deficiency anemia. This test helps determine the need for oral or intravenous iron therapy and guides further gastrointestinal evaluation.

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Area of Science:

Hematology
Gastroenterology
Clinical Diagnostics

Background:

Iron deficiency anemia is a prevalent global health issue.
While oral and intravenous iron therapies exist, iron malabsorption can hinder treatment efficacy.
Assessing oral iron absorption is crucial for effective anemia management.

Purpose of the Study:

To evaluate the utility of the oral iron absorption test (OIAT) as a straightforward and effective diagnostic tool.
To determine the degree of oral iron absorption in patients with iron deficiency anemia.

Main Methods:

The study included 81 patients diagnosed with iron deficiency anemia.
Participants received ferrous sulfate tablets.
Blood iron levels were monitored at 30-180 minute intervals post-administration.

Main Results:

Patients were categorized into three groups based on iron absorption levels: low (0-49 ug/dl), moderate (50-100 ug/dl), and high (>100 ug/dl) maximum iron increment (Cmax).

Conclusions:

The oral iron absorption test is easily performed in outpatient settings, offering clear insights into iron absorption.
Results can guide decisions on oral versus intravenous iron therapy.
The test aids in identifying the need for further gastrointestinal investigation and assessing therapeutic success.