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The prognostic role of D-dimer in hospitalized COVID-19 patients

R Korkusuz, F Karandere, S Senoglu

    Bratislavske Lekarske Listy
    |October 21, 2021
    PubMed

    Insights

    Elevated D-dimer levels in COVID-19 patients are linked to increased mortality risk. A D-dimer measurement of ≥0.5 indicated a 7.3-fold higher risk of death in hospitalized SARS-CoV-2 patients.

    Area of Science:

    • Medical Research
    • Clinical Diagnostics
    • Epidemiology

    Background:

    • Assessing prognosis in COVID-19 patients is crucial.
    • Understanding the link between D-dimer levels and COVID-19 outcomes is important for early disease management.

    Purpose of the Study:

    • To investigate the prognostic significance of D-dimer levels in hospitalized COVID-19 patients.
    • To determine if D-dimer levels can predict mortality in SARS-CoV-2 infection.

    Main Methods:

    • A cohort study of 1,669 laboratory-confirmed COVID-19 patients hospitalized between March 11 and April 20, 2020.
    • Exclusion of patients with conditions that could elevate D-dimer.
    • Logistic regression analysis to evaluate the impact of D-dimer, CRP, ferritin, and troponin on mortality.

    Main Results:

    • D-dimer levels were significantly higher in non-surviving patients.
    • A D-dimer measurement ≥0.5 was associated with a 7.325-fold increased risk of mortality.
    • The logistic regression model explained 91.3% of the variance in mortality.

    Conclusions:

    • D-dimer is an independent risk factor for mortality in COVID-19 patients.
    • Early D-dimer testing can aid in risk stratification and prognosis assessment for SARS-CoV-2 patients.
    Abstract

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