Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bones of the Lower Limb: Femur and Patella01:16

Bones of the Lower Limb: Femur and Patella

3.8K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
3.8K
Bones of the Lower Limb: Tibia and Fibula01:10

Bones of the Lower Limb: Tibia and Fibula

6.2K
The tibia is the main weight-bearing bone of the lower leg. It is larger than the fibula with which it is paired. The tibia is also the second longest bone in the body and is located right below the skin. The proximal end of the tibia forms the medial and the lateral condyle, which articulates with the condyles of the femur to form the knee joint. Between the articulating surfaces is the irregular elevated area known as the intercondylar eminence that serves as the inferior attachment point for...
6.2K
Bones of the Upper Limb: Humerus01:19

Bones of the Upper Limb: Humerus

5.6K
The upper limb consists of the arm, forearm, wrist, and hand bones. The humerus is the single bone of the upper arm region. Proximally, it has a large, spherical, smooth head that articulates with the glenoid cavity of the scapula to form the glenohumeral or shoulder joint. The margin of the head is the anatomical neck, a residual epiphyseal plate. Laterally it extends to form bony projections called the greater tubercle and the lesser tubercle. Next to the tubercles is the surgical neck, a...
5.6K
Clearance Models: Noncompartmental Models01:17

Clearance Models: Noncompartmental Models

115
Clearance is a pharmacokinetic parameter traditionally defined by compartment models, signifying the rate at which a drug is expelled from the body. However, a noncompartmental model offers an alternative method for assessing clearance, primarily employing empirical data obtained after administering a single drug dose.
The noncompartmental approach capitalizes on extensive sampling data, correlating the volume of distribution to systemic exposure and the administered dosage. This method enables...
115
Modeling and Similitude01:12

Modeling and Similitude

377
Scaled modeling is a fundamental technique in engineering, enabling the study of large and complex systems by creating smaller, manageable replicas that recreate critical characteristics of the original. In hydrology and civil infrastructure, for example, scaled models of dams help analyze water flow, turbulence, and pressure. This method allows for accurate predictions of real-world behavior within a controlled environment, significantly reducing the cost and time involved in full-scale...
377
Multicompartment Models: Overview01:14

Multicompartment Models: Overview

299
Multicompartment models are mathematical constructs that depict how drugs are distributed and eliminated within the body. They segment the body into several compartments, symbolizing various physiological or anatomical areas connected through drug transfer processes such as absorption, metabolism, distribution, and elimination.
These models offer a more comprehensive representation of drug behavior in the body than one-compartment models. They accommodate the complexity of drug distribution,...
299

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Restoring cortical disinhibition improves Huntington's disease phenotypes.

Nature·2026
Same author

Neck Motion and Injuries of Small Females and Midsize Males in Frontal Impacts at Two Severities.

Annals of biomedical engineering·2026
Same author

Injury patterns and seat belt effectiveness in pregnant motor vehicle occupants: evidence from US crash data, 1998-2021.

Injury epidemiology·2025
Same author

Validation of computational models simulating injury-related kinematics with muscle activation - obtaining data under general anaesthesia.

International journal of legal medicine·2025
Same author

Correction to: Disc Injury and Spine Loads in Low-to-Moderate-Severity Frontal Impacts.

Annals of biomedical engineering·2025
Same author

Disc Injury and Spine Loads in Low-to-Moderate-Severity Frontal Impacts.

Annals of biomedical engineering·2025

Related Experiment Video

Updated: Oct 16, 2025

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
08:20

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

Published on: March 24, 2019

8.9K

Complementing femur model validation with a variability-focused approach.

Sonja Schneider1, Jason Forman2, Steffen Peldschus1

  • 1Department of Biomechanics and Accident Analysis, University of Munich LMU, Munich, Germany.

Traffic Injury Prevention
|October 21, 2021
PubMed
Summary
This summary is machine-generated.

This study introduces a population-based clustering method to validate human body models, ensuring accurate incorporation of population variability. This approach enhances the assessment of biofidelic behavior in large-scale statistical simulations.

Keywords:
FE-modelingStochastic modelinghuman body modelvalidation approaches

More Related Videos

A Simple Critical-sized Femoral Defect Model in Mice
09:41

A Simple Critical-sized Femoral Defect Model in Mice

Published on: March 15, 2015

15.3K
A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
09:34

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

Published on: September 14, 2017

7.5K

Related Experiment Videos

Last Updated: Oct 16, 2025

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator
08:20

A Reliable and Reproducible Critical-Sized Segmental Femoral Defect Model in Rats Stabilized with a Custom External Fixator

Published on: March 24, 2019

8.9K
A Simple Critical-sized Femoral Defect Model in Mice
09:41

A Simple Critical-sized Femoral Defect Model in Mice

Published on: March 15, 2015

15.3K
A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation
09:34

A Method to Estimate Cadaveric Femur Cortical Strains During Fracture Testing Using Digital Image Correlation

Published on: September 14, 2017

7.5K

Area of Science:

  • Biomechanics
  • Computational Modeling
  • Human Body Models

Background:

  • Existing validation methods for human body models focus on individual experiment-simulation comparisons.
  • There is a need for objective methods to validate population variability incorporation in human body models.
  • Assessing the biofidelic behavior of large-number statistical simulations requires complementary validation techniques.

Purpose of the Study:

  • To present an objective, population-based approach for validating the incorporation of population variability in human body models.
  • To complement existing validation techniques by providing an additional assessment for biofidelic behavior.
  • To evaluate the quality of large-number statistical simulations with human body models.

Main Methods:

  • Utilized mathematical clustering methods to group similar response curves from combined numerical simulations and experimental data.
  • Applied the population-based approach to a reference load case: dynamic 3-point bending of the femur.
  • Assessed the biofidelic behavior of numerical simulations, including those with characteristics differing from experimental objects.

Main Results:

  • The clustering approach successfully distinguished response curves into 4 plausible groups.
  • Most experimental and numerical responses were grouped together, indicating overall agreement.
  • Three outlier response curves were identified, highlighting parameters at the population margins, consistent with experimental and anthropometric data.

Conclusions:

  • Demonstrated the feasibility of cluster analysis for validating human body models without individual comparisons.
  • The method aids in judging the agreement of finite element models with population variations, experimental, and anthropometric data.
  • Ensuring a gross match of curve shapes between simulation and experiment is crucial for biomechanical accuracy, as shown in the femur bending case.