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A synaptic temperature sensor for body cooling
Gretel B Kamm1, Juan C Boffi2, Kristina Zuza1
1Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.
Neuron
|October 21, 2021
Summary
Body temperature regulation involves hypothalamic warm-sensitive neurons (WSNs). Unexpectedly, TRPM2 channels enhance WSN temperature sensitivity via synaptic disinhibition, not directly within neurons, impacting thermoregulation.
Area of Science:
- Neuroscience
- Physiology
- Thermoregulation
Background:
- Hypothalamic warm-sensitive neurons (WSNs) are crucial for thermoregulation.
- WSN temperature sensitivity was previously thought to depend on intracellular ion channels.
Purpose of the Study:
- To investigate the synaptic mechanisms regulating WSN temperature sensitivity.
- To identify the role of TRPM2 ion channels in thermoregulation.
Main Methods:
- In vivo experiments in mice involving hypothalamic warming.
- Electrophysiological recordings to assess WSN activity and synaptic drive.
- Utilizing TRPM2 ion channel function modulation.
Main Results:
- Hypothalamic warming in vivo triggers body cooling.
- TRPM2 ion channels enhance WSN temperature responses.
- TRPM2 acts via temperature-dependent disinhibition of synaptic input to WSNs, not within WSNs.
Conclusions:
- A synaptic mechanism involving TRPM2-mediated disinhibition regulates WSN temperature sensitivity.
- This highlights a network-based approach to interoception and thermoregulation.
- Findings link WSN function directly to body temperature control via synaptic mechanisms.
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