Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Thermosensation01:43

Thermosensation

32.4K
Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
32.4K
Assessing Body Temperature - Axilla01:14

Assessing Body Temperature - Axilla

817
Procedural Guide for Assessing Axillary Body Temperature using a Digital Thermometer:
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...
817
Equipments Used to Measure Body Temperature01:13

Equipments Used to Measure Body Temperature

1.4K
Body temperature can be assessed using various devices and measured in Celsius or Fahrenheit.
Glass-bulb Thermometer:
Glass-bulb thermometers are hollow glass tubes with a bulb tip containing liquid such as ethanol or mercury. Historically, glass bulb mercury thermometers were the standard device to measure body temperature. Today, mercury thermometers are prohibited in many countries due to the hazardous effects of mercury and the risk of exposure if the glass bulb breaks. In general,...
1.4K
Body Temperature01:25

Body Temperature

3.4K
The body's temperature, measured in degrees, is determined by the balance between heat production and dissipation to the surrounding environment. For instance, if exercising vigorously, the body will produce more heat, causing sweat and dissipating that heat. Despite extreme environmental conditions and physical exertion, the human temperature-control system maintains a constant core body temperature (the temperature of deep tissues, which are the tissues located beneath the skin and other...
3.4K
Assessing Body Temperature - Temporal Artery01:19

Assessing Body Temperature - Temporal Artery

732
Here is a stepwise guide to assessing the body temperature at the temporal artery using a temporal artery thermometer
Step 1: Perform hand hygiene and don a fresh pair of gloves to prevent cross-infection and ensure patient safety.
Step 2: Explain the procedure to the patient to establish trust. Clear communication establishes trust with the patient, ensures they understand what to expect, promotes cooperation, and enhances comfort during the procedure.  
Step 3: Assess the patient's...
732
Assessing Body Temperature - Tympanic membrane01:14

Assessing Body Temperature - Tympanic membrane

811
Assessing tympanic membrane temperature involves using a tympanic membrane thermometer (TMT). Here is a step-by-step guide:
Step 1: Begin by practicing good hand hygiene to prevent the transmission of microorganisms.
Step 2: Turn on the thermometer and wait until the ready sign appears on the screen to ensure accurate measurement.
Step 3: Slide the probe cover in place to prevent cross-contamination.
Step 4: Instruct the patient to tilt their head to the side for comfort and check for cerumen...
811

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hepatitis E virus capsid protein forms amyloid-like fibrils that sequester TANK-binding kinase 1 to dampen antiviral responses.

Cell reports·2026
Same author

New evidence for Early Pleistocene use of fire at Wonderwerk Cave (South Africa).

PloS one·2026
Same author

Recombinant dimeric PICK1 peptide inhibitors for long-term relief of chronic pain by AAV therapeutics.

Cell reports. Medicine·2026
Same author

Cancer neuroscience: The past, the present, and the road ahead.

Cell·2026
Same author

Neural adaptation to climate change: mechanisms, limits and opportunities.

Nature reviews. Neuroscience·2026
Same author

Shift in motor-state equilibrium explains gait therapy effects of apomorphine in experimental Parkinsonism.

Experimental neurology·2026

Related Experiment Video

Updated: Oct 16, 2025

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation
06:33

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation

Published on: January 5, 2014

12.0K

A synaptic temperature sensor for body cooling.

Gretel B Kamm1, Juan C Boffi2, Kristina Zuza1

  • 1Department of Pharmacology, University of Heidelberg, Im Neuenheimer Feld 366, 69120 Heidelberg, Germany.

Neuron
|October 21, 2021
PubMed
Summary
This summary is machine-generated.

Body temperature regulation involves hypothalamic warm-sensitive neurons (WSNs). Unexpectedly, TRPM2 channels enhance WSN temperature sensitivity via synaptic disinhibition, not directly within neurons, impacting thermoregulation.

Keywords:
TRP ion channelsbody temperature regulationdisinhibitionhypothalamic circuithypothalamic thermoregulationinteroceptionsynaptic sensortemperature sensing

More Related Videos

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
05:32

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

Published on: November 24, 2016

8.0K
Measuring Skeletal Muscle Thermogenesis in Mice and Rats
07:56

Measuring Skeletal Muscle Thermogenesis in Mice and Rats

Published on: July 27, 2022

3.2K

Related Experiment Videos

Last Updated: Oct 16, 2025

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation
06:33

Method for Simultaneous fMRI/EEG Data Collection during a Focused Attention Suggestion for Differential Thermal Sensation

Published on: January 5, 2014

12.0K
A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device
05:32

A Detailed Protocol for Perspiration Monitoring Using a Novel, Small, Wireless Device

Published on: November 24, 2016

8.0K
Measuring Skeletal Muscle Thermogenesis in Mice and Rats
07:56

Measuring Skeletal Muscle Thermogenesis in Mice and Rats

Published on: July 27, 2022

3.2K

Area of Science:

  • Neuroscience
  • Physiology
  • Thermoregulation

Background:

  • Hypothalamic warm-sensitive neurons (WSNs) are crucial for thermoregulation.
  • WSN temperature sensitivity was previously thought to depend on intracellular ion channels.

Purpose of the Study:

  • To investigate the synaptic mechanisms regulating WSN temperature sensitivity.
  • To identify the role of TRPM2 ion channels in thermoregulation.

Main Methods:

  • In vivo experiments in mice involving hypothalamic warming.
  • Electrophysiological recordings to assess WSN activity and synaptic drive.
  • Utilizing TRPM2 ion channel function modulation.

Main Results:

  • Hypothalamic warming in vivo triggers body cooling.
  • TRPM2 ion channels enhance WSN temperature responses.
  • TRPM2 acts via temperature-dependent disinhibition of synaptic input to WSNs, not within WSNs.

Conclusions:

  • A synaptic mechanism involving TRPM2-mediated disinhibition regulates WSN temperature sensitivity.
  • This highlights a network-based approach to interoception and thermoregulation.
  • Findings link WSN function directly to body temperature control via synaptic mechanisms.