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Updated: Oct 16, 2025
An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells
Published on: July 15, 2015
Efficacy of first-line treatment options in transplant-ineligible multiple myeloma: A network meta-analysis
Szabolcs Kiss1, Noémi Gede2, Alexandra Soós2
1Doctoral School of Clinical Medicine, University of Szeged, H-6720 Szeged, Korányi fasor 8-10., Szeged, Hungary; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, H-7624 Pécs, Szigeti Street 12. 2nd floor, Hungary.
Background:
Despite major therapeutic advances, the rational choice of the most appropriate first-line regimen in newly diagnosed transplant-ineligible multiple myeloma (TIE-MM) is currently undefined.
Aim:
We aimed to identify the most effective first-line treatment for TIE-MM patients.
Methods:
A total of 37 articles, including 34 treatments and 16,681 patients, were included in this Bayesian network meta-analysis. The outcomes of interest were risk ratios (RR) for progression-free survival (PFS) and overall survival (OS).
Results:
Based on surface under cumulative ranking curve values, daratumumab-bortezomib-melphalan-prednisone (Dara-VMP) and daratumumab-lenalidomide-dexamethasone (Dara-Rd28) showed superiority compared to other combinations regarding 12-, 24-, 36-, and 48-month PFS. Dara-VMP also ranked first for 12-, 24-, 36-, and 48-month OS.
Conclusion:
Our finding supports the incorporation of daratumumab into first-line regimens. Additionally, these results highlight the relative benefit of incorporating novel agents like monoclonal antibodies, immunomodulatory derivatives, and proteasome inhibitors in combination with the currently existing treatment options.
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