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Published on: July 29, 2022
Cancer in Parkinson's Disease: An Approximation to the Main Risk Factors
Irene Rosas1, Germán Morís2,3, Eliecer Coto1,3
1Laboratorio de Genética, Hospital Universitario Central de Asturias, Oviedo, Spain.
Background:
Many evidences suggest a pathological link between neurodegenerative diseases and cancer. In fact, several epidemiologic studies indicate a decreased incidence of most cancer types in Parkinson's disease (PD) patients and some PD genes are involved in cancer networks.
Objective:
The aim of this study is to assess the influence of several factors in the risk of cancer in a cohort of 753 PD patients and to study how these variables interact with each other.
Methods:
We analyzed the effect of gender, tobacco, alcohol, type of PD (genetic or idiopathic PD), and two genetic variants, previously associated with cancer, rs5848-GRN and rs1042522-TP53.
Results:
A higher age at PD onset was observed in patients who develop cancer before PD (p < 0.001). Alcohol consumption was a risk factor to develop cancer in PD patients (p = 0.011), while smoking was not a cancer risk factor in our cohort (p = 0.098). Among the genetic factors, the genotype TT GRN-rs5848 was statistically more frequent in PD patients without cancer (p = 0.05).
Conclusions:
Our study identified several factors, genetic and nongenetic, which contribute to the risk for cancer in PD.
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