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Updated: Oct 16, 2025

Construction of a Preclinical Multimodality Phantom Using Tissue-mimicking Materials for Quality Assurance in Tumor Size Measurement
Published on: July 29, 2013
A two-layer cylinder phantom developed for film-based isocenter verification of radiotherapy machine
Zhiyue Song1, Hui Yan1, Yingjie Xu1
1Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Purpose:
A two-layer cylinder (TLC) phantom was developed for simplifying film-based isocenter verification of linear accelerators in radiotherapy.
Methods And Materials:
The phantom mainly consists of two parts: (1) two nested solid cylinders between which a radiochromic film can be inserted and irradiated; (2) a tungsten ball supported by a thin rod and located at the phantom center for alignment with the mechanical isocenter. In practice, the phantom was first positioned by the room laser to align the tungsten ball to the mechanical isocenter of the linear accelerator. Then, a radiochromic film was precisely inserted into the gap between the two cylinders of the phantom and irradiated by beams with preset gantry and couch angles. Later the irradiated film was scanned and processed by an in-house developed analysis software. Finally, the offset of the radiation isocenter from the mechanical isocenter was determined by the built-in three-dimensional (3D) reconstruction algorithms. The accuracy of this method was evaluated by positioning the phantom with a known couch shift, then checking the residual error after couch shift correction. The reliability of this method was evaluated by comparing the calculated offset with the corresponding result determined by the traditional star-shot method.
Results:
For the accuracy test, the residual errors were -0.14 ± 0.03 mm, 0.05 ± 0.06 mm, and 0.05 ± 0.06 mm in the lateral, longitudinal, and vertical axes, respectively. For the reliability test, the differences between the calculated offset and the result determined by the star-shot method were -0.10 mm, 0.12 mm, and 0.12 mm in the lateral, longitudinal, and vertical axes, respectively.
Conclusion:
The proposed method is able to reconstruct beams in 3D with one film, which is more time-saving and accurate. Additionally, with this design, the phantom positioning, film loading, beam delivery, and data analyzing are simpler. This phantom and analysis software provides an efficient and effective way to perform film-based isocenter verification of linear accelerators in radiotherapy.

