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Genome engineering in rodents - status quo and perspectives
1Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Germany.
Laboratory Animals
|October 22, 2021
Abstract:
The introduction of the CRISPR-Cas9 system in 2013 has revolutionized experimental genetics in mice and rats. This commentary gives an overview on the use of CRISPR either for gene editing in the germline or for editing and beyond editing in somatic cells. Future perspectives are opened by emerging CRISPR technologies that could enable genome engineering at larger scale.
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