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Association of total pre-existing comorbidities with stroke risk: a large-scale community-based cohort study from

Ya Zhang1,2, Cuicui Wang1,2, Dong Liu1,2

  • 1School of Public Health, Medical College of Soochow University, 199 Ren'ai Rd., Suzhou, 215123, China.

BMC Public Health
|October 22, 2021
PubMed

Insights

The number of pre-existing comorbidities independently increases stroke risk. A combination of older age and multiple comorbidities significantly elevates stroke occurrence, highlighting comorbidities as key stroke prevention indicators.

Area of Science:

  • Epidemiology
  • Cardiovascular Disease Research
  • Public Health

Background:

  • Comorbidities, or coexisting diseases, are known to increase stroke mortality.
  • The specific association between pre-existing comorbidities and the risk of developing a stroke requires further investigation.

Purpose of the Study:

  • To analyze the association between eight pre-existing comorbidities and the risk of stroke.
  • To investigate the combined effect of age and comorbidities on stroke risk.

Main Methods:

  • A prospective community-based cohort study of 16,246 adults in China.
  • Baseline survey in 2013, with follow-up via hospitalization records and death registry until 2020.
  • Cox proportional hazard models were used to analyze the association of eight comorbidities with stroke risk.

Main Results:

  • Over a median follow-up of 5.5 years, 449 participants developed a stroke.
  • Hypertension, congenital heart disease, previous stroke, and diabetes were independently associated with increased stroke risk.
  • Having one or more comorbidities significantly increased stroke risk (HR 1.96 and 2.87, respectively).

Conclusions:

  • The number of pre-existing comorbidities is independently associated with an increased risk of stroke.
  • A synergistic effect exists between increased age and a higher number of comorbidities on stroke occurrence.
  • Pre-existing comorbidities are important indicators for stroke prevention strategies.
Abstract

Keywords:
Cohort studiesPre-existing comorbidityRiskStroke

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