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Broad spectrum antimicrobial PDMS-based biomaterial for catheter fabrication
Arunmozhiarasi Armugam1, Siew Ping Teong1, Diane S W Lim1
1Institute of Bioengineering and Bioimaging, 31 Biopolis Way, The Nanos, Singapore, 138669, Singapore.
Biomaterials Research
|October 22, 2021
Summary
A new polydimethylsiloxane (PDMS)-based biomaterial effectively prevents microbial colonization on catheters for over 60 days. This biocompatible, recyclable material offers a promising solution to combat antibiotic resistance in healthcare settings.
Area of Science:
- Biomaterials Science
- Infectious Disease Research
- Polymer Chemistry
Background:
- Antibiotic resistance is a growing global health threat, exacerbated by the COVID-19 pandemic.
- Nosocomial infections, particularly those associated with invasive medical devices like urinary catheters, contribute significantly to antibiotic resistance.
- Current antibiotic-coated catheters have limitations in efficacy and available choices.
Purpose of the Study:
- To develop a novel and facile method for fabricating a polydimethylsiloxane (PDMS)-based biomaterial for antimicrobial-eluting catheters.
- To create a new polymeric imidazolium antimicrobial compound integrated into a PDMS matrix.
Main Methods:
- Fabrication of a PDMS-based biomaterial incorporating a novel polymeric imidazolium antimicrobial compound.
- Testing the biomaterial's efficacy in eradicating microbial colonization under continuous challenge.
- Evaluating the material's recyclability, long-term storage stability, and biocompatibility.
Main Results:
- The PDMS-based biomaterials demonstrated the ability to eradicate microbial colonization for up to 60 days.
- The material proved to be recyclable for multiple uses and stable for long-term storage at room temperature.
- Biocompatibility assessments confirmed the material's safety for potential medical applications.
Conclusions:
- The developed PDMS-based biomaterial exhibits significant biocidal functionality against clinically relevant microbes.
- This innovation holds promise for reducing hospital-acquired infections associated with catheters.
- The material offers a potentially more effective and versatile alternative to existing antimicrobial catheter coatings.
