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Application of Laser Micro-irradiation for Examination of Single and Double Strand Break Repair in Mammalian Cells
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Spotlight on the Disc-Damage Likelihood Scale (DDLS).

Kelvin K W Cheng1, Andrew J Tatham1

  • 1Princess Alexandra Eye Pavilion, Edinburgh, UK.

Clinical Ophthalmology (Auckland, N.Z.)
|October 22, 2021
PubMed
Summary
This summary is machine-generated.

The Disc Damage Likelihood Scale (DDLS) reliably classifies optic disc damage in glaucoma, offering better reproducibility than the cup-to-disc ratio (CDR). This review confirms its value in clinical practice for diagnosing and monitoring glaucoma.

Keywords:
cup-to-disc ratiodisc damage likelihood scaleglaucomarim-to-disc ratio

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Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Optic Nerve Imaging

Background:

  • Glaucomatous optic neuropathy requires accurate assessment of optic disc structural changes.
  • The Disc Damage Likelihood Scale (DDLS) classifies optic disc damage considering neuroretinal rim width and disc size.
  • The cup-to-disc ratio (CDR) is a common metric, but it does not account for disc size.

Purpose of the Study:

  • To critically appraise the evidence supporting the Disc Damage Likelihood Scale (DDLS).
  • To evaluate the role and clinical utility of the DDLS in current glaucoma diagnosis and monitoring practices.
  • To compare the DDLS with other glaucoma assessment methods, including the cup-to-disc ratio (CDR).

Main Methods:

  • A systematic literature search identified 33 relevant articles.
  • Studies were evaluated for reproducibility, diagnostic performance, progression detection, and correlation with other glaucoma markers.
  • Two independent authors conducted the literature search and appraisal.

Main Results:

  • The DDLS demonstrated higher reproducibility compared to the cup-to-disc ratio (CDR).
  • Evidence supports the DDLS as a reliable method for semi-quantitative clinical grading of optic disc changes in glaucoma.
  • Eleven studies examined the correlation between DDLS and other glaucoma indicators.

Conclusions:

  • The Disc Damage Likelihood Scale (DDLS) is a valuable and reproducible tool for assessing optic disc structure in glaucoma.
  • Despite advancements in imaging like OCT, clinical examination using the DDLS remains crucial for glaucoma management.
  • The DDLS provides a more comprehensive assessment than CDR by incorporating disc size.