Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omics profiling reveals systemic rejuvenation of the aged kidney through senolytic therapy.

NPJ Regenerative medicine·2026
Same author

Syntabulin promotes heart failure by enhancing SR-mitochondria tethering and impairing mitofission.

Cardiovascular research·2026
Same author

Differential Immune Priming Effects of Banana Extracellular Self-DNA Derived from Bananas with Varying Disease Severities Against <i>Fusarium oxysporum</i> f. sp. <i>cubense</i> Tropical Race 4.

Journal of fungi (Basel, Switzerland)·2026
Same author

Cationic charge regulation in nanogel networks for enhanced siRNA delivery.

Journal of colloid and interface science·2026
Same author

Identifying Ion Accessibility with Ether-Based Electrolytes to Approach Superior Rate Performance of Sulfur-Doped Carbon Anodes for Sodium-Ion Batteries.

ACS applied materials & interfaces·2026
Same author

Non-viral gene delivery systems for osteoarthritis therapy.

Biomaterials translational·2026

Related Experiment Video

Updated: Oct 16, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

733

TCPP-Isoliensinine Nanoparticles for Mild-Temperature Photothermal Therapy.

Chenglin Zhang1, Xinming Wang2, Junyou Wang2

  • 1Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 201620, People's Republic of China.

International Journal of Nanomedicine
|October 22, 2021
PubMed
Summary

This study developed novel nanoparticles combining photothermal therapy (PTT) with chemotherapy for breast cancer treatment. The combined nanoparticles effectively killed cancer cells at mild temperatures with minimal toxicity to healthy cells.

Keywords:
TCPPcombined NPsisoliensininephotothermal therapysynergistic effect

More Related Videos

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.3K
Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

138

Related Experiment Videos

Last Updated: Oct 16, 2025

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution
06:42

Plasmonic Photothermal Cancer Therapy: Nanoparticle-embedded Tumor-tissue-mimicking Phantoms for Visualizing Photothermal Temperature Distribution

Published on: May 9, 2025

733
Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
09:01

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Published on: May 22, 2020

3.3K
Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods
09:23

Inducing Targeted Mild Hyperthermia in Murine Tumor Models through Photothermal Conversion of Near-infrared Light by Intratumoral Gold Nanorods

Published on: October 10, 2025

138

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Photothermal therapy (PTT) offers localized cancer treatment but faces limitations like poor light penetration and delivery efficiency.
  • Combining PTT with chemotherapy can achieve synergistic effects for enhanced cancer treatment.

Purpose of the Study:

  • To design and evaluate novel nanoparticles for synergistic photothermal and chemotherapy in breast cancer treatment.
  • To combine tetra(4-carboxyphenyl) porphine (TCPP) as a photothermal agent and isoliensinine (Iso) as an anti-cancer drug within nanoparticles.

Main Methods:

  • TCPP and Iso were encapsulated into PEG-b-PLGA polymeric nanoparticles via a precipitation process.
  • Nanoparticle size, stability, drug release, and temperature elevation capabilities were characterized.
  • The efficacy of the nanoparticles on MDA-MB-231 breast cancer cells was assessed at mild temperatures.

Main Results:

  • The synthesized nanoparticles exhibited controlled size (65-108 nm) and good stability.
  • TCPP-Iso nanoparticles demonstrated concentration-dependent temperature elevation under laser irradiation.
  • Effective inhibition of MDA-MB-231 cell viability was observed at mild temperatures (42-43°C) with minimal damage to surrounding healthy tissues.

Conclusions:

  • TCPP-Iso combined nanoparticles show promising synergistic effects for cancer cell killing under laser irradiation.
  • These nanoparticles exhibit minimal toxicity to normal cells, suggesting potential for targeted cancer therapy.
  • The findings provide valuable insights for developing new combined photothermal agents for cancer treatment.