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LGR5-Positive Supporting Cells Survive Ototoxic Trauma in the Adult Mouse Cochlea

Natalia Smith-Cortinez1,2, Rana Yadak1,2, Ferry G J Hendriksen1

  • 1Department of Otorhinolaryngology and Head & Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.

Frontiers in Molecular Neuroscience
|October 22, 2021
PubMed

Keywords:
LGR5+ supporting cellsadult mammalian cochleadeafnessinner ear regenerationototoxicity

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Related Concept Videos

Hair Cells01:22

Hair Cells

Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
The Cochlea01:13

The Cochlea

The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.