The ISSPP PIPAC database: design, process, access, and first interim analysis

Area of Science:

• Oncology
• Surgical Oncology
• Chemotherapy Delivery

Background:

• Pressurized intraperitoneal aerosol chemotherapy (PIPAC) shows a favorable safety profile and promising clinical results for peritoneal malignancies.
• Standardized data collection is needed to enhance the quality of documentation and user acceptance of PIPAC, especially pending randomized trial outcomes.

Purpose of the Study:

• To describe the design and establishment of an international multicenter PIPAC database.
• To present the initial preliminary results from this newly developed database.

Main Methods:

• Development of a minimal dataset applicable across various diseases and conditions.
• A phased approach including design, testing, implementation, protocol, and legal requirements.
• Creation of registry rules and bylaws for the ISSPP PIPAC Registry Group.

Main Results:

• The ISSPP PIPAC online database was launched in June 2020, featuring six key data elements.
• Within the first six months, ten institutions reported on 459 PIPAC procedures in 181 patients.
• The recorded data demonstrated comparability with existing scientific literature.

Conclusions:

• A novel international multicenter PIPAC database has been successfully developed, tested, and implemented under the ISSPP.
• The database is accessible via the ISSPP website, inviting worldwide PIPAC institutions to contribute.
• This initiative aims to standardize and improve the collective understanding and application of PIPAC in treating peritoneal malignancies.