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Updated: Oct 16, 2025

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
Published on: December 11, 2016
The Rethinking Clinical Trials (REaCT) Program. A Canadian-Led Pragmatic Trials Program: Strategies for Integrating
Deanna Saunders1, Michelle Liu1, Lisa Vandermeer1
1Cancer Therapeutics Program, Ottawa Hospital Research Institute, 501 Smyth Road, Box 511, Ottawa, ON K1H 8L6, Canada.
The REaCT program effectively uses patient and health care provider surveys in breast cancer research. Electronic distribution is now standard, yielding valuable data for systematic reviews and clinical trials.
Area of Science:
- Oncology
- Health Services Research
- Clinical Trials
Background:
- Patient and health care provider (HCP) surveys are crucial for understanding breast cancer management.
- The REaCT program has a history of conducting surveys to gather insights from patients and HCPs.
Purpose of the Study:
- To review the methodology and outcomes of patient and HCP surveys conducted by the REaCT program.
- To highlight the integration of survey data into breast cancer research and clinical trial development.
Main Methods:
- Review of 15 patient surveys (2298 respondents) and 13 HCP surveys (1033 respondents) from the REaCT program.
- Analysis of survey distribution methods, duration, and response rates over time.
- Assessment of the impact of survey data on research outputs.
Main Results:
- Electronic survey distribution has become the norm, replacing paper-based methods.
- Patient surveys had a median response rate of 84%, while HCP surveys had a median response rate of 28%.
- Survey data have informed 10 systematic reviews, 6 grant applications, and 19 clinical trials.
Conclusions:
- The REaCT program successfully integrates surveys into its research process, generating valuable data for breast cancer management.
- The shift towards electronic surveys and the need for alternative distribution methods are highlighted, especially in light of the COVID-19 pandemic.
- Survey data are essential for knowledge translation and advancing clinical research in oncology.
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