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Mesoporous One-Component Gold Microshells as 3D SERS Substrates.

Anna S Vikulina1,2, Inna Y Stetsyura3, M Serdar Onses4,5

  • 1Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces, Am Mühlenberg 1, 14476 Potsdam, Germany.

Biosensors
|October 22, 2021
PubMed
Summary

Researchers developed novel porous gold microshells using hard templating for highly sensitive surface-enhanced Raman scattering (SERS) analysis. This method enables superior SERS platforms for selective detection in biomedical applications.

Keywords:
Raman spectroscopycalcium carbonatehard templatingmicroparticlesvaterite

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Area of Science:

  • Materials Science
  • Analytical Chemistry
  • Nanotechnology

Background:

  • Surface-enhanced Raman scattering (SERS) is a vital label-free analytical technique with broad applications.
  • Designing effective SERS substrates for signal amplification and selective analyte detection is crucial, especially for biomedical uses.

Purpose of the Study:

  • To introduce a novel hard templating approach for creating one-component, tailor-made SERS platforms.
  • To fabricate porous gold microparticles for enhanced SERS performance.

Main Methods:

  • Utilized mesoporous vaterite CaCO3 microcrystals as sacrificial templates.
  • Employed dual adsorption of gold nanoparticles and in situ reduction of HAuCl4.
  • Removed templates under mild conditions to yield stable, porous, one-component gold microshells.

Main Results:

  • Achieved high SERS enhancement factors of 2 × 10^8 for rhodamine B and 8 × 10^8 for bovine serum albumin.
  • Demonstrated excellent SERS performance at a low laser power of 0.4 µW.
  • Fabricated stable, mesoporous, one-component gold microshells.

Conclusions:

  • The hard templating strategy offers a scalable method for producing superior SERS platforms.
  • These platforms exhibit excellent plasmonic properties and allow for selective analyte inclusion.
  • The approach facilitates highly specific SERS analysis in various scientific fields.