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Related Concept Videos

Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

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Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
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Coronary Artery Disease II: Pathophysiology01:26

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
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Acute Coronary Syndrome III: Diagnostic Studies01:30

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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Updated: Oct 16, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
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Plasma Lipidomic Patterns in Patients with Symptomatic Coronary Microvascular Dysfunction.

Jonathan R Lindner1,2, Brian P Davidson1, Zifeng Song3

  • 1Knight Cardiovascular Institute, Oregon Health & Science University, Portland, OR 97239, USA.

Metabolites
|October 22, 2021
PubMed
Summary

Coronary microvascular dysfunction (MVD) is linked to distinct lipid profiles. Patients with MVD showed altered levels of specific triacylglycerols and diacylglycerols, offering new insights into this condition.

Keywords:
coronary artery diseaselipidomicsmicrovascular dysfunctionmyocardial contrast echocardiographymyocardial ischemia

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Area of Science:

  • Cardiology
  • Metabolomics
  • Vascular Biology

Background:

  • Coronary microvascular dysfunction (MVD) affects vascular tone regulation, especially under metabolic stress.
  • While risk factors overlap with coronary artery disease (CAD), MVD's etiology remains unclear.
  • This study investigates lipidomic profiles in symptomatic individuals without obstructive CAD.

Purpose of the Study:

  • To identify specific lipidomic signatures associated with MVD in non-elderly patients.
  • To correlate MVD, assessed by myocardial contrast echocardiography, with plasma lipid profiles.
  • To differentiate MVD lipid profiles from those in non-obstructive CAD.

Main Methods:

  • 20 patients (35-60 years) with chest pain but no obstructive CAD underwent computed tomography coronary angiography (CTA).
  • Quantitative regadenoson stress-rest myocardial contrast echocardiography (MCE) assessed MVD.
  • Plasma lipidomics was analyzed using liquid chromatography and high-resolution mass spectrometry.

Main Results:

  • Nine out of 20 subjects exhibited MVD, characterized by reduced hyperemic perfusion (1.62 ± 0.44 vs. 2.63 ± 0.99 s⁻¹, p=0.009).
  • No significant differences in non-obstructive CAD or CAD risk factors were found between MVD and non-MVD groups.
  • MVD patients displayed lower long-chain triacylglycerols/diacylglycerols and higher short-chain triacylglycerols; a specific diacylglycerol distinguished all participants.

Conclusions:

  • Distinct plasma lipidomic profiles, including saturated long-chain fatty acid-containing acylglycerols, are associated with MVD.
  • These lipid patterns differ significantly from those in non-obstructive CAD.
  • Lipidomic profiles may aid in characterizing MVD pathobiology and guiding treatment strategies.