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Mapping covariance in brain FDG uptake to structural connectivity.

Igor Yakushev1,2, Isabelle Ripp3,4, Min Wang5

  • 1Department of Nuclear Medicine, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Str. 22, Munich, 81675, Germany. igor.yakushev@tum.de.

European Journal of Nuclear Medicine and Molecular Imaging
|October 22, 2021
PubMed
Summary

Inter-subject covariance of regional 18F-fluorodeoxyglucose PET measures (FDGcov) is significantly underpinned by structural brain connectivity. White matter tracts, especially short-range ones, form the basis for approximately half of these brain connectivity patterns.

Keywords:
Diffusion tensor imagingFDG-PETNetworksPositron emission tomographyTractography

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Area of Science:

  • Neuroimaging
  • Brain Connectivity
  • Systems Neuroscience

Background:

  • Inter-subject covariance of regional 18F-fluorodeoxyglucose (FDG) PET measures (FDGcov) is increasingly used as a proxy for brain connectivity.
  • The relationship between FDGcov and underlying structural connectivity via white matter tracts remains incompletely understood.

Purpose of the Study:

  • To quantify the spatial overlap between FDGcov and structural connectivity networks.
  • To determine the extent to which white matter tracts support FDGcov-derived brain connectivity.

Main Methods:

  • Retrospective analysis of neuroimaging data from 303 subjects (patients and healthy controls).
  • Acquisition of structural MRI, diffusion tensor imaging (DTI), and FDG-PET data.
  • Estimation of FDGcov using sparse inverse covariance estimation and structural connectivity via streamline tractography.

Main Results:

  • 55% of detected whole-brain connections showed overlap between FDGcov and structural networks, significantly higher than random networks (12%).
  • 80% of intralobe connections were convergent, while only 30% of interhemispheric interlobe connections were.
  • Short-range white matter tracts were identified as a major substrate for intralobe FDGcov connections.

Conclusions:

  • Structural connectivity via white matter tracts is a significant substrate for FDGcov, accounting for approximately half of whole-brain connections.
  • Short-range white matter tracts play a crucial role in establishing intralobe functional connectivity patterns reflected in FDGcov.