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Updated: Oct 16, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
Receptors and ligands for herpes simplex viruses: Novel insights for drug targeting
Yiwei Huang1, Yuyun Song1, Jichen Li2
1School of Clinical Medicine, Weifang Medical University, Weifang 261053, China.
Abstract:
Human herpes simplex viruses (HSVs) belong to the Herpesviridae family. At present, no vaccine or curative treatment is available for the prevention of HSV infections. Here, we review the cell surface receptors that are recognized by HSV's glycoprotein B, glycoprotein C, glycoprotein D, and the glycoprotein H - glycoprotein L complex to facilitate entry into host cells. These receptors include heparan sulfate (HS), herpesvirus entry mediator (HVEM), and nectin-1/-2, 3-O-sulfated heparan sulfate (3-OS HS).
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