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Teladorsagia Circumcincta Galectin-Mucosal Interactome in Sheep
Nur Nasuha Hafidi1,2, Jaclyn Swan1,2, Pierre Faou3
1Department of Animal, Plant and Soil Science and Centre for AgriBioscience (AgriBio), La Trobe University, Bundoora 3086, Australia.
Veterinary Sciences
|October 22, 2021
Summary
Teladorsagia circumcincta, a key livestock parasite, secretes Tci-gal-1, a protein interacting with host proteins. Identifying these interactions offers insights into host-parasite dynamics and potential control strategies.
Area of Science:
- Veterinary Parasitology
- Molecular Biology
- Immunology
Background:
- Teladorsagia circumcincta is a major gastrointestinal parasite causing significant economic losses in livestock.
- Infective larvae secrete excretory-secretory (E/S) molecules, including Tci-gal-1, which may modulate host immunity.
- Tci-gal-1 shares similarities with mammalian galectins, known regulators of cellular functions like inflammation and immune responses.
Purpose of the Study:
- To investigate the role of Tci-gal-1 at the host-parasite interface.
- To identify host proteins that interact with Tci-gal-1.
Main Methods:
- Proteomics pull-down assays were employed.
- Interacting proteins were identified from sheep abomasal scrapes and whole tissue samples.
Main Results:
- A total of 135 unique proteins were identified from whole abomasal tissue and 89 from abomasal scrapes.
- 63 host proteins were common to both sample types.
- Identified host proteins include trefoil factors and mucin-like proteins crucial for host response.
Conclusions:
- The study identified Tci-gal-1 binding partners, revealing new aspects of host-parasite interactions.
- Understanding these interactions may pave the way for novel strategies to control Teladorsagia circumcincta infections.
