Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Oct 16, 2025

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.1K

Letter to the Editor.

N Smallwood1

  • 1Consultant Acute Medicine, Surrey and Sussex Healthcare NHS Trust.

Acute Medicine
|October 22, 2021
PubMed
Summary
This summary is machine-generated.

Systemic thrombolytic therapy may benefit patients with massive or submassive pulmonary embolism (PE). However, current guidelines restrict its use to high-risk PE cases, excluding hemodynamically stable individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Tackling burnout in Australian doctors by blending a web-based cognitive-behavioural therapy program with telehealth psychological support - protocol for a three-arm randomised-controlled trial.

Contemporary clinical trials communications·2025
Same author

Substantial variety in point of care ultrasound training across EFIM.

European journal of internal medicine·2025
Same author

Culture, conditions and care support mental health of healthcare workers during crises.

Occupational medicine (Oxford, England)·2024
Same author

Point of care ultrasound: Current and future directions for Acute Medicine.

Acute medicine·2023
Same author

Point-of-care lung ultrasound in the assessment of COVID-19: results of a UK multicentre service evaluation.

Acute medicine·2022
Same author

'Just another asthma attack?' - point of care ultrasound as a game changer in respiratory failure.

Acute medicine·2022
Same journal

Procalcitonin use in Acute Medicine in the United Kingdom: a survey of practice, barriers and facilitators.

Acute medicine·2026
Same journal

What does a job in Acute Medicine look like? Insights from the RCP 2023 Workforce Census.

Acute medicine·2026
Same journal

Embedding penicillin de-labelling in the AMU: a feasibility and safety pilot study with exploratory economic and environmental analysis.

Acute medicine·2026
Same journal

'Not All Swellings Are Angioedema' - An Overview And Systematic Approach For Acute Medical Physicians.

Acute medicine·2026
Same journal

The experiences of international medical graduates (IMGs) new to the NHS: an interpretive phenomenological analysis.

Acute medicine·2026
Same journal

Editorial - Differential attainment in training in the United Kingdom.

Acute medicine·2026
See all related articles

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Medical Guidelines

Background:

  • Recent research suggests potential benefits of thrombolytic therapy for massive and submassive pulmonary embolism (PE).
  • Current UK National Institute for Health and Care Excellence (NICE) guidelines advise against systemic thrombolytic therapy for hemodynamically stable PE patients, even with right ventricular dysfunction.

Purpose of the Study:

  • To evaluate the discrepancy between emerging research on thrombolytic therapy for PE and existing clinical guidelines.
  • To clarify the recommended indications for thrombolytic therapy in pulmonary embolism based on current evidence and guidelines.

Main Methods:

  • Review of recent literature on thrombolytic therapy in pulmonary embolism.
  • Analysis of current NICE and European Society of Cardiology (ESC) guidelines for PE management.

More Related Videos

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases
04:25

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Published on: November 8, 2024

2.0K
Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

8.1K

Related Experiment Videos

Last Updated: Oct 16, 2025

Perspectives on Neuroscience
26:41

Perspectives on Neuroscience

Published on: July 31, 2007

5.1K
Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases
04:25

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Published on: November 8, 2024

2.0K
Focal Laser Ablation of Prostate Cancer: An Office Procedure
11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

8.1K

Main Results:

  • Apsey et al. highlight potential benefits of thrombolysis in massive and submassive PE.
  • NICE guidance explicitly contraindicates systemic thrombolysis for hemodynamically stable PE.
  • Both NICE and European guidelines reserve routine thrombolysis for high-risk (previously 'massive') PE.

Conclusions:

  • There is a divergence between recent findings and established guidelines regarding thrombolysis for PE.
  • Current consensus strongly favors thrombolysis only for high-risk pulmonary embolism.