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Updated: Oct 16, 2025
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Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
Published on: April 12, 2019
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Osteosarcoma mechanobiology and therapeutic targets
Zunaira Shoaib1, Timothy M Fan2,3, Joseph M K Irudayaraj3,4,5
1Department of Pathobiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
British Journal of Pharmacology
|October 22, 2021
Summary
Mechanobiology influences osteosarcoma progression and metastasis. Understanding these mechanical cues and mechanobiology-based therapies, including 3D models, can improve osteosarcoma treatment and patient survival rates.
Area of Science:
- Oncology
- Biophysics
- Biomaterials
Background:
- Osteosarcoma is a primary bone tumor with poor prognosis, especially with metastasis.
- Paget's disease shares skeletal features with osteosarcoma, suggesting a role for bone microenvironment.
- Prognosis varies by location, highlighting the bone microenvironment's role in pathogenesis.
Purpose of the Study:
- To review the contribution of mechanobiology to osteosarcoma progression.
- To discuss current mechanobiology-based therapies for osteosarcoma.
- To explore potential new therapeutic targets and 3D models for studying osteosarcoma mechanobiology.
Main Methods:
- Literature review on mechanobiology in osteosarcoma.
- Analysis of current mechanobiology-driven therapies.
- Summary of 3D models used in osteosarcoma mechanobiology research.
Main Results:
- Mechanobiology plays a significant role in osteosarcoma progression and metastasis.
- Mechanobiology-based therapies can alter the physical microenvironment or inhibit metastasis.
- Various 3D models are employed to study osteosarcoma mechanobiology.
Conclusions:
- Mechanobiology is crucial in osteosarcoma pathogenesis and progression.
- Targeting mechanobiology offers promising therapeutic strategies.
- Advanced 3D models are essential for studying osteosarcoma mechanobiology and developing new treatments.
Keywords:
3D cell culturebisphosphonatesbone remodellingbone sarcomamechanobiologymechanotransductionosteosarcomapharmacologytherapyMore Related Videos
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