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Evaluating Sequential Response Learning in the Rodent Operant Touchscreen System.

Helena Janickova¹, Ornela Kljakic^1,2, Trevor W Robbins³

¹Robarts Research Institute, Schulich School of Medicine & Dentistry, University of Western Ontario, London, Ontario, Canada.

Current Protocols

|October 22, 2021

Summary

This summary is machine-generated.

This study details a touchscreen protocol for assessing sequential response learning in rodents. The heterogeneous sequence task evaluates complex motor learning and striatal signaling essential for behavior.

Keywords:

mouse response chain sequential learning touchscreen

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Area of Science:

Neuroscience
Behavioral Neuroscience
Animal Models

Background:

Sequential and cue-directed response learning in rodents are critically dependent on striatal signaling.
These behaviors involve striatal dopamine and acetylcholine release, with impairments observed in models with altered signaling.
Previous research highlights the role of these neurotransmitter systems in sequential learning.

Purpose of the Study:

To provide a detailed protocol for testing sequential response/response chain learning in rodents using a touchscreen system.
To adapt and implement the heterogeneous sequence task for rodent touchscreen apparatus.
To establish a standardized method for assessing complex motor learning and response selection.

Main Methods:

Utilized a touchscreen-based automated chamber with five response locations.
Employed food reinforcement to maintain task performance.
Adapted the heterogeneous sequence task, requiring five sequential nose pokes to visual stimuli.

Main Results:

The protocol successfully implements the heterogeneous sequence task in a rodent touchscreen paradigm.
Demonstrated the feasibility of assessing sequential learning and response selection in mice.
Established a reproducible method for studying the neurobiological underpinnings of sequential behavior.

Conclusions:

The described touchscreen protocol offers a robust method for investigating sequential response learning in rodents.
This task is valuable for studying the role of striatal signaling in complex motor learning.
The protocol facilitates research into the neurochemical basis of behavior and potential therapeutic targets.