Related Experiment Video
Updated: Oct 16, 2025

07:27
Anterior Segment Organ Culture Platform for Tracking Open Globe Injuries and Therapeutic Performance
Published on: August 25, 2021
2.1K
Open Globe Injuries: Classifications and Prognostic Factors for Functional Outcome.
Christian Steffen Mayer1, Lukas Reznicek2, Isabella Diana Baur1
1Department of Ophthalmology, Heidelberg University, 69120 Heidelberg, Germany.
Diagnostics (Basel, Switzerland)
|October 23, 2021
Summary
Posterior segment involvement significantly worsens visual outcomes in open globe injuries. Factors for good vision include initial visual acuity and limited injury zones (I and II).
Area of Science:
- Ophthalmology
- Trauma Surgery
- Public Health
Background:
- Open globe injuries represent a significant cause of vision loss.
- Understanding prognostic factors is crucial for managing these severe ocular traumas.
- Epidemiological data and injury characteristics inform treatment strategies.
Purpose of the Study:
- To explore the epidemiology of open globe injuries.
- To evaluate posterior segment involvement as a prognostic factor for functional outcome.
- To identify predictors of visual acuity following open globe injuries.
Main Methods:
- Retrospective analysis of 151 patients with open globe injuries.
- Data collected included demographics, injury classification (Ocular Trauma Score - OTS), surgical procedures, intraocular pressure (IOP), and corrected distance visual acuity (CDVA).
- Correlation analyses were performed between OTS and postoperative CDVA, with a focus on posterior segment involvement.
Main Results:
- The study included 147 eyes; mean age was 42.9 years, with 78.2% males. Workplace injuries accounted for 36.7%.
- Posterior segment involvement (retina, optic nerve) was observed in a significant proportion of patients.
- Patients with posterior segment involvement had significantly worse postoperative CDVA (1.523 ± 0.654 logMAR) compared to those without (0.944 ± 0.708 logMAR), p < 0.01.
Conclusions:
- Posterior segment involvement is a critical negative prognostic factor for visual outcome in open globe injuries.
- Good initial corrected distance visual acuity and injuries limited to zones I and II are predictive of better visual outcomes.
- These findings underscore the importance of assessing posterior segment status for patient management and prognostication.
Related Concept Videos
Glaucoma: Overview
964
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
964
Open Angle Glaucoma: Treatment
750
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
750

