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Hyperbaric Oxygen Treatment-From Mechanisms to Cognitive Improvement
Irit Gottfried1, Nofar Schottlender1,2, Uri Ashery1,2
1School of Neurobiology, Biochemistry and Biophysics, Life Sciences Faculty, Tel Aviv University, Tel Aviv 6997801, Israel.
Biomolecules
|October 23, 2021
Summary
Hyperbaric oxygen treatment (HBOT) is a proven therapy for various conditions and is increasingly used for brain health. Research shows HBOT impacts cellular processes, offering potential for neurological disorders and cognitive enhancement.
Area of Science:
- Neurology
- Hyperbaric Medicine
- Cellular Biology
Background:
- Hyperbaric oxygen treatment (HBOT) involves breathing pure oxygen at increased atmospheric pressure.
- HBOT is established for conditions like carbon monoxide poisoning, non-healing wounds, and smoke inhalation.
- Emerging applications include improving cognition and quality of life after brain trauma and stroke.
Purpose of the Study:
- To review the basic mechanisms of HBOT.
- To discuss HBOT's effects on cellular processes.
- To explore HBOT's role in treating brain disorders and enhancing cognitive function.
Main Methods:
- Review of existing clinical and basic research studies on HBOT.
- Analysis of HBOT's impact on cellular mechanisms, including mitochondrial function, oxidative stress, and inflammation.
- Examination of HBOT's therapeutic effects on neurological conditions and cognitive performance.
Main Results:
- HBOT influences key cellular processes, transcription factors, and mitochondrial function.
- Evidence suggests HBOT can mitigate oxidative stress and inflammation.
- Studies indicate HBOT's efficacy in improving cognitive function and brain metabolism.
Conclusions:
- HBOT is a significant therapeutic modality with expanding applications in neurology.
- Understanding HBOT's cellular mechanisms provides a basis for its clinical use in brain disorders.
- HBOT shows promise for treating neurodegenerative diseases and mild cognitive impairment in the elderly.
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