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Related Experiment Video

Updated: Oct 16, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

Oligonucleotides-Based Therapeutics.

Bernard Lebleu¹

¹Laboratory of Pathogen Host Interactions, Université Montpellier, UMR 5235 CNRS, 34000 Montpellier, France.

|October 23, 2021

Summary

Nucleic-acid-based strategies are revolutionizing medicine by enabling precise gene expression regulation. These innovative approaches are paving the way for a new era of targeted therapies.

Area of Science:

Molecular Biology
Genetics
Pharmacology

Background:

Nucleic acids offer precise tools for modulating gene expression.
Emerging nucleic-acid-based therapies represent a novel class of medicines.

Discussion:

Exploring the mechanisms of action for various nucleic-acid-based strategies.
Addressing challenges in delivery and stability for therapeutic applications.
Highlighting the potential to target previously undruggable genetic disorders.

Key Insights:

Gene expression regulation via nucleic acids is a rapidly advancing field.
These strategies offer unprecedented specificity in therapeutic interventions.
The development of nucleic-acid-based medicines is transforming personalized medicine.

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Published on: September 21, 2017

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

Related Experiment Videos

Last Updated: Oct 16, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

Published on: July 28, 2017

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

Published on: September 21, 2017

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization

Published on: April 3, 2014

Outlook:

Future research directions in optimizing nucleic-acid-based therapies.
Expanding the therapeutic landscape for genetic diseases.
Integration of artificial intelligence in designing novel nucleic-acid drugs.