Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

487
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
487
Overview of Exosomes01:36

Overview of Exosomes

2.9K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cannabinoid 2 Receptor Activation Mitigates High-Fat Diet/Streptozotocin-Induced Nonalcoholic Fatty Liver Disease in Diabetic Mice by Modulation of Oxidative Stress, Inflammation, and Fibrosis.

ACS pharmacology & translational science·2026
Same author

Correction: Barani et al. Nanomaterials in the Management of Gram-Negative Bacterial Infections. <i>Nanomaterials</i> 2021, <i>11</i>, 2535.

Nanomaterials (Basel, Switzerland)·2026
Same author

Pharmacological Mechanisms of Phytochemicals and Pharmaceutical Agents in Protecting Against Methotrexate-Induced Liver Injury.

Oxidative medicine and cellular longevity·2026
Same author

Foodborne Mycotoxins as Molecular and Epigenetic Carcinogens: Biochemical Mechanisms and Toxicological Implications.

Journal of biochemical and molecular toxicology·2026
Same author

Farnesol, a Dietary Sesquiterpene, Attenuates Rotenone-Induced Dopaminergic Neurodegeneration by Inhibiting Oxidative Stress, Inflammation, and Apoptosis via Mediation of Cell Signaling Pathways in Rats.

International journal of molecular sciences·2026
Same author

Decoding chronic pain: insights into the transition from acute to persistent pain.

Open biology·2026

Related Experiment Video

Updated: Oct 16, 2025

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

579

Extracellular Vesicle-Based Therapy for COVID-19: Promises, Challenges and Future Prospects.

Vamika Karn1, Shaista Ahmed2, Lung-Wen Tsai3,4

  • 1Department of Biotechnology, Amity University, Mumbai 410221, India.

Biomedicines
|October 23, 2021
PubMed
Summary

Extracellular vesicles (EVs), including exosomes, show promise as cell-free therapies against COVID-19. These nano-carriers may mitigate severe symptoms like cytokine storms and aid in patient recovery.

Keywords:
COVID-19SARS-CoV2extracellular vesiclestherapeutic agents

More Related Videos

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

954
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

249

Related Experiment Videos

Last Updated: Oct 16, 2025

Characterizing Extracellular Vesicles from Biological Fluids
05:07

Characterizing Extracellular Vesicles from Biological Fluids

Published on: February 28, 2025

579
Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics
08:50

Scalable Biomanufacturing Workflow to Produce and Isolate Natural Killer Cell-Derived Extracellular Vesicle-Based Cancer Biotherapeutics

Published on: August 16, 2024

954
Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy
07:33

Enhancing Chimeric Antigen Receptor-Extracellular Vesicles (CAR-EV) Technology: The Future of Cancer Therapy

Published on: September 19, 2025

249

Area of Science:

  • Biomedical research
  • Nanotechnology
  • Immunology

Background:

  • COVID-19 poses significant public health and economic challenges, primarily affecting the lungs and potentially causing organ failure and death.
  • Effective therapeutic strategies are urgently needed for COVID-19 management.
  • Extracellular vesicles (EVs) mediate intercellular communication and have shown therapeutic potential in inflammatory conditions.

Purpose of the Study:

  • To review the current progress and challenges of using extracellular vesicles (EVs) as a therapeutic agent for COVID-19.
  • To highlight the potential of exosomes, a subclass of EVs, in treating COVID-19 pathogenesis.
  • To assess the safety and efficacy of EVs in ongoing clinical trials for COVID-19.

Main Methods:

  • Comprehensive literature review of studies and clinical trials on EVs for COVID-19.
  • Analysis of EV properties, including their role in intercellular communication and therapeutic effects.
  • Evaluation of exosome characteristics relevant to drug delivery and therapeutic applications.

Main Results:

  • EVs derived from various sources can suppress the cytokine storm in severe COVID-19.
  • EVs promote alveolar fluid clearance, epithelial/endothelial recovery, and cell proliferation.
  • Exosomes exhibit favorable characteristics for cell-free therapy, including targeting, biocompatibility, and low immunogenicity.

Conclusions:

  • Extracellular vesicles, particularly exosomes, represent a promising cell-free therapeutic strategy for COVID-19.
  • Further research and clinical trials are essential to establish the safety and efficacy of EVs in managing COVID-19.
  • EVs offer a potential avenue for combating the severe pathological consequences of COVID-19.