Related Experiment Video

Updated: Oct 16, 2025

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays
04:07

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays

Published on: February 24, 2023

1.9K

Genomic Consideration in Chemotherapy-Induced Ovarian Damage and Fertility Preservation

Seongmin Kim1, Sanghoon Lee2, Hyun-Tae Park2

  • 1Gynecologic Cancer Center, CHA Ilsan Medical Center, CHA University College of Medicine, 1205 Jungang-ro, Ilsandong-gu, Goyang-si 10414, Korea.

Genes
|October 23, 2021
PubMed

Insights

Chemotherapy can damage ovaries in young cancer patients by affecting genes involved in follicle health. Understanding these genomic changes is key to developing fertility preservation strategies.

Area of Science:

  • Reproductive medicine
  • Genomics
  • Oncology

Background:

  • Chemotherapy-induced ovarian damage impacts fertility in young cancer patients.
  • Understanding the genomic mechanisms of ovarian damage is crucial for developing targeted prevention strategies.

Purpose of the Study:

  • To review the genomic aspects of chemotherapy-induced ovarian damage.
  • To highlight the importance of multidisciplinary oncofertility strategies for young female cancer patients.

Main Methods:

  • Literature review of studies on genomic alterations and ovarian damage.
  • Analysis of molecular pathways involved in follicular apoptosis and follicle activation.

Main Results:

  • Gene alterations linked to follicular apoptosis and accelerated follicle activation contribute to ovarian insufficiency.
  • Chemotherapy can accelerate follicular apoptosis, deplete the follicle reserve, and damage ovarian stroma through molecular pathways.

Conclusions:

  • Genomic factors play a significant role in chemotherapy-induced ovarian damage.
  • Multidisciplinary oncofertility approaches are essential for preserving fertility and ensuring high-quality care for young female cancer survivors.
Keywords:
chemotherapycryopreservationfertility preservationgenegonadotoxicitymutationoncofertility

More Related Videos

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives08:46

Fertility Preservation Through Oocyte Vitrification: Clinical and Laboratory Perspectives

Published on: September 16, 2021

6.2K
Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation05:42

Z-Scores for Assessing Ovarian Reserve in Young Patients Undergoing Fertility Preservation

Published on: October 25, 2024

1.3K

Related Concept Videos

Oogenesis02:07

Oogenesis

In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
66.3K
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
8.1K
Infertility in Females01:28

Infertility in Females

Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
2.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.2K