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Ole Isacson: Development of New Therapies for Parkinson's Disease
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Genetically Targeted Clinical Trials in Parkinson's Disease: Learning from the Successes Made in Oncology

Magnus Sjögren1,2, Henri J Huttunen1, Per Svenningsson3

  • 1Herantis Pharma Plc, Bertel Jungin Aukio 1, 02600 Espoo, Finland.

Genes
|October 23, 2021
PubMed

Insights

Clinical trials for neurodegenerative diseases like Parkinson's disease (PD) can improve by adopting precision medicine strategies. Applying oncology trial designs, genetics, and biomarkers can enhance success rates for PD treatments.

Area of Science:

  • Neuroscience
  • Clinical Pharmacology
  • Genetics

Background:

  • Neurodegenerative disorder clinical trials face high failure rates.
  • Oncology has achieved success through precision medicine and genetically defined subtypes.
  • Parkinson's disease (PD) has over 20 associated genes and a known pathophysiology.

Purpose of the Study:

  • To review methods used in oncology clinical trials.
  • To examine current attempts in Parkinson's disease clinical trials.
  • To explore the potential of implementing precision medicine in neurodegenerative disease research.

Main Methods:

  • Review of oncology clinical trial methodologies.
  • Analysis of Parkinson's disease clinical trial designs and outcomes.
  • Discussion of genetic and biomarker applications in neurodegenerative research.

Main Results:

  • Oncology trials demonstrate success with targeted therapies.
  • Early applications of precision medicine in PD show promise.
  • Genetics and biomarkers are crucial for stratifying patients and identifying targets.

Conclusions:

  • Precision medicine approaches from oncology can be adapted for neurodegenerative disorders.
  • Integrating genetics, biomarkers, and smart trial designs is key to improving PD clinical trial success.
  • Further research is needed to fully implement these strategies in neurodegenerative disease clinical trials.
Keywords:
Parkinson’s diseaseclinical trialsgenetic targetsneurodegenerative disordersoncologyprecision medicine

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