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IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives
Michal Španko1,2, Karolína Strnadová1,3, Aleš Jan Pavlíček1,4
1Institute of Anatomy, First Faculty of Medicine, Charles University, 12800 Prague, Czech Republic.
Abstract:
Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.
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