Related Experiment Video

Updated: Oct 16, 2025

Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
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Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization

Published on: December 23, 2020

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Molecular Insights on the Possible Role of Annexin A2 in COVID-19 Pathogenesis and Post-Infection Complications

Prakash Patil1, Praveenkumar Shetty1,2, Nithin Kuriakose3

  • 1Central Research Laboratory, KS Hegde Medical Academy (KSHEMA), NITTE (Deemed to be University), Mangalore 575018, India.

International Journal of Molecular Sciences
|October 23, 2021
PubMed

Insights

Annexin A2 (AnxA2) plays a role in SARS-CoV-2 infection, impacting viral entry and replication. Understanding AnxA2's molecular interactions may reveal new antiviral targets for COVID-19 treatment.

Area of Science:

  • Virology
  • Molecular Biology
  • Biochemistry

Background:

  • Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has caused a global pandemic, with limited antiviral treatments available.
  • Understanding the molecular mechanisms of viral pathogenesis and post-infection complications is crucial for developing effective therapies.

Purpose of the Study:

  • To investigate the potential role of Annexin A2 (AnxA2) in SARS-CoV-2 infection.
  • To explore the molecular interactions between AnxA2 and SARS-CoV-2 components.
  • To provide insights into AnxA2's involvement in COVID-19 pathogenesis and complications.

Main Methods:

  • Literature review on AnxA2 involvement in viral infections.
  • In silico molecular docking of SARS-CoV-2 spike glycoprotein and RNA-dependent RNA polymerase with human AnxA2.

Main Results:

  • AnxA2, a phospholipid-binding protein, is implicated in SARS-CoV-2 attachment, internalization, and replication.
  • In silico docking revealed molecular interactions between viral proteins and AnxA2.
  • AnxA2 may contribute to SARS-CoV-2 pathogenesis and post-infection issues like thrombosis and cytokine storm.

Conclusions:

  • AnxA2 is a potential key player in SARS-CoV-2 pathogenesis.
  • Targeting AnxA2 interactions could offer novel therapeutic strategies against COVID-19.
  • Further research into AnxA2's role in complications like thrombosis and insulin resistance is warranted.
Keywords:
Annexin A2COVID-19SARS-CoV-2cytokine storminfectioninsulin resistancepathogenesisthrombosis

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