Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

123
Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
123
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

94
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
94
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

73
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
73
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

105
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
105
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

65
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
65
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

64
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
64

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Extracellular Vesicles Link Cerebral Ischemia to Coronary Microvascular Dysfunction - Role for RGD Motif-Activated Endothelin Signaling.

Journal of cardiovascular translational research·2026
Same author

Titin modulation and left ventricular remodelling in chronic primary mitral regurgitation.

Frontiers in cardiovascular medicine·2026
Same author

Cardiac Amyloidosis: Pathogenesis, Diagnosis, and Treatment.

Deutsches Arzteblatt international·2026
Same author

From Diagnostic Mimicry to Diagnostic Clarity: Reframing Idiopathic Ventricular Fibrillation After Aborted Sudden Cardiac Death.

JACC. Case reports·2026
Same author

Smoking and outcomes in MINOCA: Clarifying the smoker's paradox in a heterogeneous population.

Kardiologia polska·2026
Same author

Correction to: Myosin-Inhibitor Mavacamten Acutely Enhances Cardiomyocyte Diastolic Compliance in Heart Failure With Preserved Ejection Fraction.

Circulation. Heart failure·2026

Related Experiment Video

Updated: Oct 16, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K

Cardiomyocyte Dysfunction in Inherited Cardiomyopathies.

Roua Hassoun1,2, Heidi Budde1,2, Andreas Mügge1,2

  • 1Institut für Forschung und Lehre (IFL), Molecular and Experimental Cardiology, Ruhr University Bochum, 44801 Bochum, Germany.

International Journal of Molecular Sciences
|October 23, 2021
PubMed
Summary

Inherited cardiomyopathies, often caused by sarcomeric protein gene defects, impair heart function. Understanding these genetic alterations is key to developing new therapies and improving patient prognostication.

Keywords:
cardiomyocyte mechanicsinherited cardiomyopathiesmutationssarcomeric proteins

More Related Videos

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
08:37

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.

Published on: March 3, 2021

4.6K
Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.4K

Related Experiment Videos

Last Updated: Oct 16, 2025

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples
14:39

Isolation and Functional Characterization of Human Ventricular Cardiomyocytes from Fresh Surgical Samples

Published on: April 21, 2014

17.5K
Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.
08:37

Sarcomere Shortening of Pluripotent Stem Cell-Derived Cardiomyocytes using Fluorescent-Tagged Sarcomere Proteins.

Published on: March 3, 2021

4.6K
Isolation and Physiological Analysis of Mouse Cardiomyocytes
11:02

Isolation and Physiological Analysis of Mouse Cardiomyocytes

Published on: September 7, 2014

23.4K

Area of Science:

  • Cardiology
  • Genetics
  • Molecular Biology

Background:

  • Inherited cardiomyopathies are diverse heart muscle disorders affecting cardiac structure and function.
  • Sarcomeric protein gene defects are primary drivers of contractile dysfunction and disease progression.

Purpose of the Study:

  • To review the functional consequences of inherited cardiomyopathies on myocardial contraction and kinetics.
  • To highlight structural and functional alterations in sarcomeric variants contributing to disease pathogenesis.
  • To focus on mutation-induced changes in cardiomyocyte mechanics.

Main Methods:

  • Literature review of inherited cardiomyopathies.
  • Analysis of sarcomeric protein variants and their impact on cardiac function.
  • Examination of mutation-induced alterations in cardiomyocyte mechanics.

Main Results:

  • Sarcomeric gene defects lead to significant perturbations in myocardial contraction and kinetics.
  • Specific sarcomeric variants exhibit distinct structural and functional alterations driving disease.
  • Mutations directly impact cardiomyocyte mechanics, contributing to cardiomyopathy development.

Conclusions:

  • Understanding the molecular basis of inherited cardiomyopathies is crucial for therapeutic development.
  • Novel agents targeting sarcomere contractility are emerging.
  • Early genetic defect identification improves patient prognostication and disease prevention.