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Mitochondrial myopathy presenting as temporomandibular dysfunction.

J E Van Sickels, A B Gruber, K S Kagan-Hallet

    Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
    |February 1, 1987
    PubMed
    Summary
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    Facial pain may indicate underlying systemic myopathy, not just temporomandibular dysfunction. Early diagnosis of hereditary myopathies like mitochondrial myopathy is crucial for effective treatment.

    Area of Science:

    • Neurology
    • Genetics
    • Pathology

    Background:

    • Orofacial pain is often diagnosed as temporomandibular dysfunction.
    • Systemic myopathies can present with facial pain symptoms.

    Observation:

    • Three patients with orofacial pain initially diagnosed with temporomandibular dysfunction underwent muscle biopsies.
    • Biopsies revealed underlying pathologic abnormalities, suggesting a different diagnosis.

    Findings:

    • A number of patients with facial pain may have an undiagnosed systemic myopathy.
    • This myopathy can be hereditary with unusual inheritance patterns.
    • Mitochondrial myopathy is one example of such a condition.

    Implications:

    • Clinicians treating facial pain should consider the possibility of underlying systemic myopathies.

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  • Awareness of hereditary myopathies is essential for accurate diagnosis and management.
  • Further research into the genetic basis and presentation of myopathies causing facial pain is warranted.