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Updated: Oct 16, 2025

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
Published on: March 25, 2016
Hodgkin Lymphoma: A Special Microenvironment
Giuseppina Opinto1, Claudio Agostinelli2,3, Sabino Ciavarella1
1Haematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy.
Abstract:
Classical Hodgkin's lymphoma (cHL) is one of the most particular lymphomas for the few tumor cells surrounded by an inflammatory microenvironment. Reed-Sternberg (RS) and Hodgkin (H) cells reprogram and evade antitumor mechanisms of the normal cells present in the microenvironment. The cells of microenvironment are essential for growth and survival of the RS/H cells and are recruited through the effect of cytokines/chemokines. We summarize recent advances in gene expression profiling (GEP) analysis applied to study microenvironment component in cHL. We also describe the main therapies that target not only the neoplastic cells but also the cellular components of the background.
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