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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
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Updated: Oct 16, 2025

Neutrophil Isolation and Analysis to Determine their Role in Lymphoma Cell Sensitivity to Therapeutic Agents
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Hodgkin Lymphoma: A Special Microenvironment.

Giuseppina Opinto1, Claudio Agostinelli2,3, Sabino Ciavarella1

  • 1Haematology and Cell Therapy Unit, IRCCS-Istituto Tumori 'Giovanni Paolo II', 70124 Bari, Italy.

Journal of Clinical Medicine
|October 23, 2021
PubMed
Summary

Classical Hodgkin's lymphoma involves unique tumor cells within an inflammatory microenvironment. Therapies now target both cancer cells and the supporting microenvironment components for improved treatment.

Keywords:
Classical Hodgkin’s lymphomagene expression profilingmicroenvironmenttherapy

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Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Classical Hodgkin's lymphoma (cHL) is characterized by rare tumor cells within a reactive inflammatory microenvironment.
  • Reed-Sternberg (RS) and Hodgkin (H) cells manipulate the microenvironment, evading immune responses.
  • Cytokines and chemokines are crucial for recruiting microenvironment cells, supporting RS/H cell growth and survival.

Purpose of the Study:

  • To review recent advancements in gene expression profiling (GEP) for analyzing the cHL microenvironment.
  • To discuss current and emerging therapies targeting both neoplastic cells and microenvironment components in cHL.

Main Methods:

  • Gene expression profiling (GEP) analysis of cHL samples.
  • Review of therapeutic strategies targeting cHL.

Main Results:

  • GEP analysis provides insights into the cellular composition and function of the cHL microenvironment.
  • Understanding microenvironment interactions is key to cHL pathogenesis.
  • Therapeutic strategies are evolving to incorporate microenvironment modulation.

Conclusions:

  • The inflammatory microenvironment is integral to cHL development and progression.
  • Targeting the microenvironment alongside neoplastic cells offers promising therapeutic avenues.
  • GEP is a valuable tool for dissecting the complex cHL ecosystem.