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Related Concept Videos

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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Related Experiment Video

Updated: Oct 16, 2025

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Capsaicin 8% Patch and Chronic Postsurgical Neuropathic Pain.

Luca Gregorio Giaccari1, Caterina Aurilio1, Francesco Coppolino1

  • 1Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", 80138 Napoli, Italy.

Journal of Personalized Medicine
|October 23, 2021
PubMed
Summary

The capsaicin 8% patch effectively reduces chronic post-surgical pain (CPSP). This treatment is safe and well-tolerated, though more research is needed.

Keywords:
Qutenza®capsaicin 8% patchchronic post-surgical pain (CPSP)

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Area of Science:

  • Pain Management
  • Neurology
  • Dermatology

Background:

  • Chronic post-surgical pain (CPSP) is a common complication following surgical procedures.
  • The capsaicin 8% patch is an approved treatment for neuropathic pain conditions like postherpetic neuralgia and diabetic peripheral neuropathy.
  • Literature review is needed to assess the efficacy of the capsaicin 8% patch for CPSP.

Purpose of the Study:

  • To review existing literature on the use of the capsaicin 8% patch for treating neuropathic pain associated with surgery.
  • To evaluate the effectiveness and safety of the capsaicin 8% patch in managing chronic post-surgical pain.

Main Methods:

  • A systematic literature search was conducted using keywords such as 'capsaicin 8% patch', 'Qutenza', and 'chronic postsurgical pain'.
  • 14 studies reporting on 632 cases of CPSP treated with the capsaicin 8% patch were identified and analyzed.

Main Results:

  • Treatment with the capsaicin 8% patch led to a significant reduction in average pain intensity for patients with CPSP.
  • Adverse events were reported in only 5 studies, with erythema, burning sensation, and pain being the most common.
  • The capsaicin 8% patch demonstrated a favorable safety and tolerability profile.

Conclusions:

  • The capsaicin 8% patch appears to be an effective and safe treatment option for chronic post-surgical pain.
  • Further randomized controlled trials are recommended to confirm the efficacy, safety, and tolerability of this treatment for CPSP.