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The Diagnostic Value of 99mTc-HMPAO-Labelled White Blood Cell Scintigraphy and 18F-FDG PET/CT in Cardiac

Katarzyna Holcman1,2, Paweł Rubiś2, Agnieszka Stępień2

  • 1Department of Nuclear Medicine, John Paul II Hospital, 31-202 Krakow, Poland.

Journal of Personalized Medicine
|October 23, 2021
PubMed

Insights

Molecular imaging techniques, including technetium-99m-hexamethylpropyleneamine oxime-labeled autologous leukocytes SPECT/CT and 18F-FDG PET/CT, show high accuracy in diagnosing cardiac device-related infective endocarditis (CDRIE). These methods can improve patient work-up for this challenging complication.

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Infectious Diseases

Background:

  • Cardiac implantable electronic device (CIED) implantation for arrhythmias can lead to complications.
  • Cardiac device-related infective endocarditis (CDRIE) presents significant diagnostic and management challenges.
  • Molecular imaging may offer enhanced insights into CDRIE diagnosis.

Purpose of the Study:

  • To systematically review and appraise the diagnostic performance of hybrid molecular imaging techniques for CDRIE.
  • To evaluate the evidence for 99mTc-HMPAO-SPECT/CT and 18F-FDG PET/CT in CDRIE diagnosis.

Main Methods:

  • Systematic literature review adhering to PRISMA and GRADE criteria.
  • Searched PubMed, Embase, and Cochrane databases for relevant studies.
  • Included 18 studies presenting original data on 99mTc-HMPAO-SPECT/CT or 18F-FDG PET/CT for CDRIE diagnosis.

Main Results:

  • Analysis of 18 studies (published 1971-2021) identified from 2131 initial records.
  • Both 99mTc-HMPAO-SPECT/CT and 18F-FDG PET/CT demonstrated high diagnostic accuracy for CDRIE.
  • Inclusion of these molecular imaging modalities improves the diagnostic work-up for CDRIE.

Conclusions:

  • 99mTc-HMPAO-SPECT/CT and 18F-FDG PET/CT offer significant diagnostic value in identifying patients at risk of CDRIE.
  • These molecular imaging techniques should be considered for integration into the CDRIE diagnostic process.

Keywords:
18F-FDG PET/CT99mTc-HMPAO-SPECT/CTCDRIEHMPAOSPECTcardiac device-related infective endocarditisinfective endocarditisscintigraphy

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