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Computational Simulations in Advanced Microfluidic Devices: A Review.

Violeta Carvalho1,2, Raquel O Rodrigues3, Rui A Lima1,4

  • 1MEtRICs, Campus de Azurém, University of Minho, 4800-058 Guimarães, Portugal.

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Summary

Numerical simulations enhance understanding of complex biological processes in biomedical engineering. This review highlights advances in organ-on-a-chip devices, noting limitations in current simulation details and reproducibility.

Keywords:
computational simulationsdrug discoverymicrofluidic devicesnumerical simulationsorgan-on-a-chippreclinical models

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Area of Science:

  • Biomedical Engineering
  • Computational Science

Background:

  • Numerical simulations are vital tools in engineering, particularly in biomedical applications.
  • Computational methods accelerate the study of complex biological phenomena difficult to investigate experimentally.

Purpose of the Study:

  • To review recent progress in numerical studies of advanced microfluidic devices.
  • To assess the utility of these studies in understanding physical processes and developing organ-on-a-chip (OoC) platforms.

Main Methods:

  • Literature review of numerical studies on microfluidic devices.
  • Analysis of simulation methodologies and their impact on understanding physical processes.

Main Results:

  • Numerical simulations offer detailed insights into phenomena like heat transfer, shear stress, and diffusion.
  • Significant advances have been made in applying computational tools to preclinical platforms.

Conclusions:

  • Numerical studies are crucial for advancing organ-on-a-chip (OoC) technology.
  • Improvements are needed in simulation detail and reporting to enhance reproducibility and model development.