Related Experiment Video
Updated: Oct 15, 2025
07:27
Recurrent Herpetic Stromal Keratitis in Mice, a Model for Studying Human HSK
Published on: December 18, 2012
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Chronic and Recurrent Herpes Zoster Ophthalmicus
Soo Min Lee1,2, Jisang Han3, Chan Min Yang2
1Nunemiso Eye Center, Seoul 06241, Korea.
Medicina (Kaunas, Lithuania)
|October 23, 2021
Summary
Herpes zoster ophthalmicus (HZO) frequently becomes chronic or recurs. Chronic HZO, particularly with epithelial or stromal keratitis and elevated intraocular pressure, significantly increases recurrence risk.
Area of Science:
- Ophthalmology
- Virology
- Immunology
Background:
- Herpes zoster ophthalmicus (HZO) can lead to chronic and recurrent disease, impacting patient outcomes.
- Understanding the natural course and risk factors for HZO chronicity and recurrence is crucial for effective management.
Purpose of the Study:
- To investigate the incidence of chronic and recurrent HZO.
- To identify risk factors associated with chronic and recurrent HZO.
- To evaluate the impact of long-term treatments on HZO recurrence.
Main Methods:
- Retrospective review of medical charts for 130 HZO patients.
- Multivariable-adjusted logistic and Cox regression models were employed.
- Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to determine risk factors.
Main Results:
- 23.85% of patients experienced chronic HZO, and 14.62% had recurrent HZO.
- Chronic HZO, epithelial keratitis, stromal keratitis, and increased intraocular pressure (IOP) were significant risk factors for recurrence.
- Neither systemic antiviral therapy nor anti-inflammatory eyedrops were associated with reduced recurrence.
Conclusions:
- A substantial proportion of HZO cases develop into chronic or recurrent conditions.
- Chronic HZO, characterized by epithelial/stromal keratitis and elevated IOP, significantly elevates the risk of recurrence.
- Current long-term treatment strategies showed no significant association with reduced HZO recurrence in this cohort.
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