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Vancomycin Use in Children and Neonates across Three Decades: A Bibliometric Analysis of the Top-Cited Articles

Chiara Minotti1, Elisa Barbieri1, Carlo Giaquinto1

  • 1Division of Pediatric Infectious Diseases, Department of Women's and Children's Health, University of Padova, 35100 Padova, Italy.

Pathogens (Basel, Switzerland)
|October 23, 2021
PubMed

Insights

This review highlights current evidence on vancomycin use in pediatric and neonatal intensive care units (ICUs), focusing on severe infections and antibiotic resistance. Emerging research addresses optimized dosing strategies for these vulnerable populations.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Pharmacology

Background:

  • Vancomycin is a critical antibiotic for Gram-positive bacterial infections in pediatric patients, particularly in intensive care units (ICUs).
  • Understanding current evidence and knowledge gaps is crucial for optimizing vancomycin therapy in neonates and children.

Purpose of the Study:

  • To systematically review and analyze highly cited articles on vancomycin use in pediatric and infectious disease literature.
  • To identify key research themes, publication trends, and knowledge gaps concerning vancomycin in pediatric populations.

Main Methods:

  • Bibliometric analysis of top-cited articles (≥30 citations) published in the last three decades.
  • Searched leading journals in "pediatrics" and "infectious diseases" based on 2019 Journal Citation Reports.

Main Results:

  • 115 articles were analyzed, published in 21 journals, with a median impact factor of 4.6.
  • Primary topics included bloodstream/invasive infections and antibiotic resistance (MRSA treatment).
  • A significant portion focused on neonates (27 articles) and children (27 articles), predominantly from ICU settings.

Conclusions:

  • Current literature emphasizes vancomycin for severe infections and antibiotic resistance, especially in neonatal ICUs.
  • There is a growing research interest in novel dosing strategies for vancomycin in pediatric and neonatal populations.

Keywords:
bibliometric analysischildrenneonatespediatric infectious diseasestop-cited articlesvancomycin

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